Matches in SemOpenAlex for { <https://semopenalex.org/work/W2434339917> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W2434339917 endingPage "36" @default.
- W2434339917 startingPage "127" @default.
- W2434339917 abstract "Nine investigated chlorobromine-, bromine-, and dibromine-ifosfamide analogues including 3 racemates and 6 enantiomers, caused about 10-fold increase in in vitro cytotoxic activity, similar to reference standards ifosfamide and cyclophosphamide in HeLa (KB) human tumor cell culture systems with the addition of rat liver microsomal preparations (ED50 = 0.11 - 0.27 x 10(-3) mole/l) as compared to microsomally non induced samples. The chlorobromine-analogues (ED50 = 0.11 - 0.20 x 10(-3) mole/l) demonstrated the highest cytotoxicity in comparison with bromine-, or dibromine-analogues (SAR). Their levorotatory (-)-(S)- enantiomers (ED50 = 0.11 : 0.21 : 0.24 x 10(-3) mole/l) appear to be more active than their dextrorotatory (+)-(R)-antipodes (ED50 = 0.20 : 0.26 : 0.27 x 10(-3) mole/l, respectively) (ESAR). The stereodifferentiated enhancement of their in vitro cytotoxicity, correlated with the decreasing of in vivo L1210 antileukemic effect following phenobarbital metabolic induction in terms of a whole--strong antitumor activity, indicate that their cytostatic activity depends enantioselectively on the mixed function oxidases-system activity, and presumably on the efficacy of the rate of drug metabolic transformation to their cytostatically active metabolites/intermediates." @default.
- W2434339917 created "2016-06-24" @default.
- W2434339917 creator A5007307278 @default.
- W2434339917 creator A5021618485 @default.
- W2434339917 creator A5038401306 @default.
- W2434339917 date "1997-03-01" @default.
- W2434339917 modified "2023-09-23" @default.
- W2434339917 title "Enantioselective cytotoxic activity of bromine-substituted analogues of ifosfamide. A microsomal implication." @default.
- W2434339917 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9437759" @default.
- W2434339917 hasPublicationYear "1997" @default.
- W2434339917 type Work @default.
- W2434339917 sameAs 2434339917 @default.
- W2434339917 citedByCount "2" @default.
- W2434339917 crossrefType "journal-article" @default.
- W2434339917 hasAuthorship W2434339917A5007307278 @default.
- W2434339917 hasAuthorship W2434339917A5021618485 @default.
- W2434339917 hasAuthorship W2434339917A5038401306 @default.
- W2434339917 hasConcept C109316439 @default.
- W2434339917 hasConcept C150903083 @default.
- W2434339917 hasConcept C178790620 @default.
- W2434339917 hasConcept C185592680 @default.
- W2434339917 hasConcept C202751555 @default.
- W2434339917 hasConcept C207001950 @default.
- W2434339917 hasConcept C2776694085 @default.
- W2434339917 hasConcept C2777366897 @default.
- W2434339917 hasConcept C2777506904 @default.
- W2434339917 hasConcept C2778119113 @default.
- W2434339917 hasConcept C42533223 @default.
- W2434339917 hasConcept C486523 @default.
- W2434339917 hasConcept C517835270 @default.
- W2434339917 hasConcept C54355233 @default.
- W2434339917 hasConcept C55493867 @default.
- W2434339917 hasConcept C71240020 @default.
- W2434339917 hasConcept C86803240 @default.
- W2434339917 hasConcept C87644729 @default.
- W2434339917 hasConcept C98274493 @default.
- W2434339917 hasConceptScore W2434339917C109316439 @default.
- W2434339917 hasConceptScore W2434339917C150903083 @default.
- W2434339917 hasConceptScore W2434339917C178790620 @default.
- W2434339917 hasConceptScore W2434339917C185592680 @default.
- W2434339917 hasConceptScore W2434339917C202751555 @default.
- W2434339917 hasConceptScore W2434339917C207001950 @default.
- W2434339917 hasConceptScore W2434339917C2776694085 @default.
- W2434339917 hasConceptScore W2434339917C2777366897 @default.
- W2434339917 hasConceptScore W2434339917C2777506904 @default.
- W2434339917 hasConceptScore W2434339917C2778119113 @default.
- W2434339917 hasConceptScore W2434339917C42533223 @default.
- W2434339917 hasConceptScore W2434339917C486523 @default.
- W2434339917 hasConceptScore W2434339917C517835270 @default.
- W2434339917 hasConceptScore W2434339917C54355233 @default.
- W2434339917 hasConceptScore W2434339917C55493867 @default.
- W2434339917 hasConceptScore W2434339917C71240020 @default.
- W2434339917 hasConceptScore W2434339917C86803240 @default.
- W2434339917 hasConceptScore W2434339917C87644729 @default.
- W2434339917 hasConceptScore W2434339917C98274493 @default.
- W2434339917 hasIssue "2-3" @default.
- W2434339917 hasLocation W24343399171 @default.
- W2434339917 hasOpenAccess W2434339917 @default.
- W2434339917 hasPrimaryLocation W24343399171 @default.
- W2434339917 hasRelatedWork W1982027601 @default.
- W2434339917 hasRelatedWork W2012485659 @default.
- W2434339917 hasRelatedWork W2039268413 @default.
- W2434339917 hasRelatedWork W2124779454 @default.
- W2434339917 hasRelatedWork W2277318871 @default.
- W2434339917 hasRelatedWork W2350027679 @default.
- W2434339917 hasRelatedWork W2375409372 @default.
- W2434339917 hasRelatedWork W2406246266 @default.
- W2434339917 hasRelatedWork W2434339917 @default.
- W2434339917 hasRelatedWork W2896620171 @default.
- W2434339917 hasVolume "49" @default.
- W2434339917 isParatext "false" @default.
- W2434339917 isRetracted "false" @default.
- W2434339917 magId "2434339917" @default.
- W2434339917 workType "article" @default.