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- W2434428816 abstract "The study was conducted in apparently healthy, non-dyslipidemic subjects, but with high levels of high-sensitivity C-reactive protein (hsCRP), and showed a decrease in LDL cholesterol and hsCRP of 55% and 36%, respectively, with administration of rosuvastatin at standard doses (20 mg/die), with a significant reduction in incidence of major cardiovascular events. The event reduction was maximal in patients whose LDL cholesterol and hsCRP levels were lowered to < 70 mg/dl and <2 mg/I, respectively. The publication of data resulted in a wide debate within international scientific community, particularly related to clinical implications of major findings. The main implications seem to be confirmation of the lower is better philosophy and of role of hsCRP as a marker to select, among intermediate risk subjects, patients who are actually at higher risk, who need to be treated with highly effective statins with a low side-effect profile, such as rosuvastatin. Patients with JUPITER phenotype (metabolic syndrome + family history of cardiovascular disease) seem to benefit most from a treatment that includes measurement of hsCRP and rosuvastatin administration." @default.
- W2434428816 created "2016-06-24" @default.
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- W2434428816 date "2009-12-01" @default.
- W2434428816 modified "2023-09-23" @default.
- W2434428816 title "[JUPITER, what now?]." @default.
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