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• W2434557777 abstract "Senile plaques comprised of Aβ peptides are a hallmark of Alzheimer's disease (AD) brain, as are activated glia that release inflammatory molecules, including eicosanoids. Previous studies have demonstrated that amyloid precursor protein (APP) and Aβ levels can be increased through activation of thromboxane A2-prostanoid (TP) receptors on neurons. We demonstrate that TP receptor regulation of APP expression depends on Gαq-signaling and conventional protein kinase C isoforms. Importantly, we discovered that Gαq-linked prostaglandin E2 and leukotriene D4 receptors also regulate APP expression. Prostaglandin E2 and thromboxane A2, as well as total APP levels, were found to be elevated in the brains of aged 5XFAD transgenic mice harboring Aβ plaques and activated glia, suggesting that increased APP expression resulted from eicosanoid binding to Gαq-linked neuronal receptors. Notably, inhibition of eicosanoid synthesis significantly lowered brain APP protein levels in aged 5XFAD mice. These results provide new insights into potential AD therapeutic strategies." @default.
• W2434557777 created "2016-06-24" @default.
• W2434557777 creator A5006491544 @default.
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• W2434557777 creator A5078341013 @default.
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• W2434557777 date "2015-12-17" @default.
• W2434557777 modified "2023-10-16" @default.
• W2434557777 title "Inflammatory Eicosanoids Increase Amyloid Precursor Protein Expression via Activation of Multiple Neuronal Receptors" @default.
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• W2434557777 doi "https://doi.org/10.1038/srep18286" @default.
• W2434557777 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4682150" @default.
• W2434557777 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26672557" @default.
• W2434557777 hasPublicationYear "2015" @default.
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