FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2434706925> ?p ?o ?g. }

• W2434706925 endingPage "94" @default.
• W2434706925 startingPage "88" @default.
• W2434706925 abstract "Previous studies linking telomere length (TL) and health have been largely associational. We apply genetic instrumental variables (IV) analysis, also known as Mendelian randomization, to test the hypothesis that shorter TL leads to poorer health. This method reduces bias from reverse causation or confounding. We used two approaches in this study that rely on two separate data sources: (1) individual-level data from the Health and Retirement Study (HRS) (N = 3734), and (2) coefficients from genome-wide association studies (GWAS). We employed two-sample genetic IV analyses, constructing a polygenic risk score (PRS) of TL-associated single nucleotide polymorphisms. The first approach examined the association of the PRS with nine individual health outcomes in HRS. The second approach took advantage of estimates available in GWAS databases to estimate the impact of TL on five health outcomes using an inverse variance-weighted meta-analytic technique. Using individual-level data, shorter TL was marginally statistically significantly associated with decreased risk of stroke and increased risk of heart disease. Using the meta-analytic approach, shorter TL was associated with increased risk of coronary artery disease (OR 1.02 per 100 base pairs, 95%CI: 1.00, 1.03). With the exception of a small contribution to heart disease, our findings suggest that TL may be a marker of disease rather than a cause. They also demonstrate the utility of the inverse variance-weighted meta-analytic approach when examining small effect sizes." @default.
• W2434706925 created "2016-06-24" @default.
• W2434706925 creator A5023908200 @default.
• W2434706925 creator A5047818687 @default.
• W2434706925 creator A5081540617 @default.
• W2434706925 date "2016-09-01" @default.
• W2434706925 modified "2023-10-17" @default.
• W2434706925 title "Telomere length and health outcomes: A two-sample genetic instrumental variables analysis" @default.
• W2434706925 cites W1043653796 @default.
• W2434706925 cites W135250288 @default.
• W2434706925 cites W1497143641 @default.
• W2434706925 cites W1579661837 @default.
• W2434706925 cites W1897447385 @default.
• W2434706925 cites W1905058580 @default.
• W2434706925 cites W1922949753 @default.
• W2434706925 cites W1972696558 @default.
• W2434706925 cites W1975502679 @default.
• W2434706925 cites W1979112102 @default.
• W2434706925 cites W1980442558 @default.
• W2434706925 cites W1983552452 @default.
• W2434706925 cites W1987554776 @default.
• W2434706925 cites W1988141264 @default.
• W2434706925 cites W1993467061 @default.
• W2434706925 cites W1993893889 @default.
• W2434706925 cites W1994873752 @default.
• W2434706925 cites W1997338841 @default.
• W2434706925 cites W2000764314 @default.
• W2434706925 cites W2005421391 @default.
• W2434706925 cites W2024809912 @default.
• W2434706925 cites W2027208491 @default.
• W2434706925 cites W2033149855 @default.
• W2434706925 cites W2036623477 @default.
• W2434706925 cites W2039153962 @default.
• W2434706925 cites W2049680139 @default.
• W2434706925 cites W2052193672 @default.
• W2434706925 cites W2060501426 @default.
• W2434706925 cites W2063448719 @default.
• W2434706925 cites W2065692954 @default.
• W2434706925 cites W2066598075 @default.
• W2434706925 cites W2090897293 @default.
• W2434706925 cites W2091267313 @default.
• W2434706925 cites W2094430244 @default.
• W2434706925 cites W2100555170 @default.
• W2434706925 cites W2104208781 @default.
• W2434706925 cites W2107476202 @default.
• W2434706925 cites W2112848098 @default.
• W2434706925 cites W2115783720 @default.
• W2434706925 cites W2118743532 @default.
• W2434706925 cites W2126054772 @default.
• W2434706925 cites W2127141263 @default.
• W2434706925 cites W2136303436 @default.
• W2434706925 cites W2139875520 @default.
• W2434706925 cites W2144320201 @default.
• W2434706925 cites W2145859123 @default.
• W2434706925 cites W2147991226 @default.
• W2434706925 cites W2149634356 @default.
• W2434706925 cites W2151872224 @default.
• W2434706925 cites W2159843609 @default.
• W2434706925 cites W2160566988 @default.
• W2434706925 cites W2166794708 @default.
• W2434706925 cites W2171385020 @default.
• W2434706925 cites W2325080052 @default.
• W2434706925 cites W2332303329 @default.
• W2434706925 cites W2507752161 @default.
• W2434706925 cites W3202551943 @default.
• W2434706925 cites W605291159 @default.
• W2434706925 doi "https://doi.org/10.1016/j.exger.2016.06.005" @default.
• W2434706925 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4969151" @default.
• W2434706925 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27321645" @default.
• W2434706925 hasPublicationYear "2016" @default.
• W2434706925 type Work @default.
• W2434706925 sameAs 2434706925 @default.
• W2434706925 citedByCount "22" @default.
• W2434706925 countsByYear W24347069252016 @default.
• W2434706925 countsByYear W24347069252017 @default.
• W2434706925 countsByYear W24347069252018 @default.
• W2434706925 countsByYear W24347069252019 @default.
• W2434706925 countsByYear W24347069252020 @default.
• W2434706925 countsByYear W24347069252022 @default.
• W2434706925 crossrefType "journal-article" @default.
• W2434706925 hasAuthorship W2434706925A5023908200 @default.
• W2434706925 hasAuthorship W2434706925A5047818687 @default.
• W2434706925 hasAuthorship W2434706925A5081540617 @default.
• W2434706925 hasBestOaLocation W24347069252 @default.
• W2434706925 hasConcept C104317684 @default.
• W2434706925 hasConcept C105795698 @default.
• W2434706925 hasConcept C106208931 @default.
• W2434706925 hasConcept C126322002 @default.
• W2434706925 hasConcept C129848803 @default.
• W2434706925 hasConcept C135763542 @default.
• W2434706925 hasConcept C144024400 @default.
• W2434706925 hasConcept C149923435 @default.
• W2434706925 hasConcept C153209595 @default.
• W2434706925 hasConcept C162144332 @default.
• W2434706925 hasConcept C186413461 @default.
• W2434706925 hasConcept C2779134260 @default.
• W2434706925 hasConcept C2779901538 @default.
• W2434706925 hasConcept C2780176501 @default.

• next