Matches in SemOpenAlex for { <https://semopenalex.org/work/W2434854545> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W2434854545 endingPage "11" @default.
- W2434854545 startingPage "801" @default.
- W2434854545 abstract "Studies were undertaken in mice to determine the effect of calusterone (a weakly androgenic steroid) on hemopoiesis. Animals were myelosuppressed with a single injection of the alkylating agent busulfan and subsequently treated with varying courses of calusterone. Simultaneous injection of calusterone did not prevent the rapid decline in CFU-S or CFU-C. Daily administration of calusterone for 12 to 14 days after busulfan had little influence on bone marrow cellularity; however, a twofold increase in peripheral blood neutrophils was observed. Bone marrow CFU-S and CFU-C were twofold to threefold higher after 8 to 14 days of treatment with calusterone, but there were no progressive increments in these hemopoietic stem cells during this time interval. In contrast to the granulocyte series, erythroid recovery was rapid after busulfan. Marrow erythroid precursors and CFU-E returned to normal levels by day 8. Daily treatment with calusterone accelerated recovery and led to an overshoot in these parameters of marrow erythropoiesis. Although an early course of calusterone treatment had only modest effects on CFU-S and CFU-C, delayed treatment was clearly stimulatory. A 10-day course of calusterone from days 14 to 24 after busulfan increased bone marrow CFU-S and CFU-C from 5% to 23% of controls to near normal values. Thus calusterone appears to stimulate all classes of hemopoietic progenitor cells. Its effects after busulfan are highly time-dependent, with greatest activity observed in those cellular compartments undergoing proliferative expansion." @default.
- W2434854545 created "2016-06-24" @default.
- W2434854545 creator A5007791464 @default.
- W2434854545 creator A5010410939 @default.
- W2434854545 creator A5048920631 @default.
- W2434854545 creator A5065276222 @default.
- W2434854545 creator A5068178591 @default.
- W2434854545 date "1981-06-01" @default.
- W2434854545 modified "2023-09-23" @default.
- W2434854545 title "The effects of calusterone on hemopoiesis in mice after busulfan-induced suppression of hemopoietic stem cells." @default.
- W2434854545 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6453178" @default.
- W2434854545 hasPublicationYear "1981" @default.
- W2434854545 type Work @default.
- W2434854545 sameAs 2434854545 @default.
- W2434854545 citedByCount "1" @default.
- W2434854545 crossrefType "journal-article" @default.
- W2434854545 hasAuthorship W2434854545A5007791464 @default.
- W2434854545 hasAuthorship W2434854545A5010410939 @default.
- W2434854545 hasAuthorship W2434854545A5048920631 @default.
- W2434854545 hasAuthorship W2434854545A5065276222 @default.
- W2434854545 hasAuthorship W2434854545A5068178591 @default.
- W2434854545 hasConcept C109159458 @default.
- W2434854545 hasConcept C126322002 @default.
- W2434854545 hasConcept C134018914 @default.
- W2434854545 hasConcept C16685009 @default.
- W2434854545 hasConcept C201750760 @default.
- W2434854545 hasConcept C203014093 @default.
- W2434854545 hasConcept C2776694085 @default.
- W2434854545 hasConcept C2776755627 @default.
- W2434854545 hasConcept C2777557582 @default.
- W2434854545 hasConcept C2777983669 @default.
- W2434854545 hasConcept C2778248108 @default.
- W2434854545 hasConcept C2779703530 @default.
- W2434854545 hasConcept C2779863229 @default.
- W2434854545 hasConcept C2780007613 @default.
- W2434854545 hasConcept C2780611847 @default.
- W2434854545 hasConcept C28328180 @default.
- W2434854545 hasConcept C71924100 @default.
- W2434854545 hasConcept C86803240 @default.
- W2434854545 hasConcept C95444343 @default.
- W2434854545 hasConceptScore W2434854545C109159458 @default.
- W2434854545 hasConceptScore W2434854545C126322002 @default.
- W2434854545 hasConceptScore W2434854545C134018914 @default.
- W2434854545 hasConceptScore W2434854545C16685009 @default.
- W2434854545 hasConceptScore W2434854545C201750760 @default.
- W2434854545 hasConceptScore W2434854545C203014093 @default.
- W2434854545 hasConceptScore W2434854545C2776694085 @default.
- W2434854545 hasConceptScore W2434854545C2776755627 @default.
- W2434854545 hasConceptScore W2434854545C2777557582 @default.
- W2434854545 hasConceptScore W2434854545C2777983669 @default.
- W2434854545 hasConceptScore W2434854545C2778248108 @default.
- W2434854545 hasConceptScore W2434854545C2779703530 @default.
- W2434854545 hasConceptScore W2434854545C2779863229 @default.
- W2434854545 hasConceptScore W2434854545C2780007613 @default.
- W2434854545 hasConceptScore W2434854545C2780611847 @default.
- W2434854545 hasConceptScore W2434854545C28328180 @default.
- W2434854545 hasConceptScore W2434854545C71924100 @default.
- W2434854545 hasConceptScore W2434854545C86803240 @default.
- W2434854545 hasConceptScore W2434854545C95444343 @default.
- W2434854545 hasIssue "6" @default.
- W2434854545 hasLocation W24348545451 @default.
- W2434854545 hasOpenAccess W2434854545 @default.
- W2434854545 hasPrimaryLocation W24348545451 @default.
- W2434854545 hasRelatedWork W1980421076 @default.
- W2434854545 hasRelatedWork W2004838691 @default.
- W2434854545 hasRelatedWork W2035629708 @default.
- W2434854545 hasRelatedWork W2076228354 @default.
- W2434854545 hasRelatedWork W2400016491 @default.
- W2434854545 hasRelatedWork W2434854545 @default.
- W2434854545 hasRelatedWork W2885148134 @default.
- W2434854545 hasRelatedWork W3212318684 @default.
- W2434854545 hasRelatedWork W1968377433 @default.
- W2434854545 hasRelatedWork W2395528375 @default.
- W2434854545 hasVolume "97" @default.
- W2434854545 isParatext "false" @default.
- W2434854545 isRetracted "false" @default.
- W2434854545 magId "2434854545" @default.
- W2434854545 workType "article" @default.