Matches in SemOpenAlex for { <https://semopenalex.org/work/W2434905930> ?p ?o ?g. }
Showing items 1 to 68 of
68
with 100 items per page.
- W2434905930 endingPage "95" @default.
- W2434905930 startingPage "187" @default.
- W2434905930 abstract "Healthy nicotine-dependent smokers were applied different doses of transdermal nicotine systems (TNS) during single and repeated administrations. Plasma and urine nicotine and cotinine concentrations were determined by high performance liquid chromatography (HPLC). After single application of TNS, the maximal concentration (Cmax) and area under curve (AUC) of nicotine in plasma as well as the amount of nicotine excreted in urine were linearly related to the dose. The stable urinary cotinine excretion was not influenced by the amount of nicotine delivered by the TNS. The relevant 24 h plasma nicotine concentration reached after TNS application compares well with the plasma nicotine footpoints--not the peaks--observed in moderate to heavy cigarette smokers. A comparison between different nicotine doses from different TNS allowed to conclude to the functionality of the systems as regards pharmacokinetics and bioavailability. One or two hours after removal of the systems, there was a very slow decline of the nicotine concentrations. After repeated application of TNS, there was evidence for only a very limited nicotine accumulation in plasma (+14%) or in urine (+9%) over 10 days. The steady-state of nicotine was reached within 4 days. The continuous delivery of nicotine over 24 h resulted in an early morning plasma concentration which probably decreases or prevents the craving for the first cigarette." @default.
- W2434905930 created "2016-06-24" @default.
- W2434905930 creator A5003359936 @default.
- W2434905930 creator A5012164701 @default.
- W2434905930 creator A5036691668 @default.
- W2434905930 creator A5048911583 @default.
- W2434905930 creator A5074001626 @default.
- W2434905930 date "1989-03-01" @default.
- W2434905930 modified "2023-09-23" @default.
- W2434905930 title "Pharmacokinetics and bioavailability of nicotine in healthy volunteers following single and repeated administration of different doses of transdermal nicotine systems." @default.
- W2434905930 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2725117" @default.
- W2434905930 hasPublicationYear "1989" @default.
- W2434905930 type Work @default.
- W2434905930 sameAs 2434905930 @default.
- W2434905930 citedByCount "13" @default.
- W2434905930 crossrefType "journal-article" @default.
- W2434905930 hasAuthorship W2434905930A5003359936 @default.
- W2434905930 hasAuthorship W2434905930A5012164701 @default.
- W2434905930 hasAuthorship W2434905930A5036691668 @default.
- W2434905930 hasAuthorship W2434905930A5048911583 @default.
- W2434905930 hasAuthorship W2434905930A5074001626 @default.
- W2434905930 hasConcept C10146269 @default.
- W2434905930 hasConcept C112705442 @default.
- W2434905930 hasConcept C126322002 @default.
- W2434905930 hasConcept C181389837 @default.
- W2434905930 hasConcept C185592680 @default.
- W2434905930 hasConcept C205679159 @default.
- W2434905930 hasConcept C22979827 @default.
- W2434905930 hasConcept C2776319443 @default.
- W2434905930 hasConcept C2779547902 @default.
- W2434905930 hasConcept C2780026642 @default.
- W2434905930 hasConcept C55493867 @default.
- W2434905930 hasConcept C71924100 @default.
- W2434905930 hasConcept C98274493 @default.
- W2434905930 hasConceptScore W2434905930C10146269 @default.
- W2434905930 hasConceptScore W2434905930C112705442 @default.
- W2434905930 hasConceptScore W2434905930C126322002 @default.
- W2434905930 hasConceptScore W2434905930C181389837 @default.
- W2434905930 hasConceptScore W2434905930C185592680 @default.
- W2434905930 hasConceptScore W2434905930C205679159 @default.
- W2434905930 hasConceptScore W2434905930C22979827 @default.
- W2434905930 hasConceptScore W2434905930C2776319443 @default.
- W2434905930 hasConceptScore W2434905930C2779547902 @default.
- W2434905930 hasConceptScore W2434905930C2780026642 @default.
- W2434905930 hasConceptScore W2434905930C55493867 @default.
- W2434905930 hasConceptScore W2434905930C71924100 @default.
- W2434905930 hasConceptScore W2434905930C98274493 @default.
- W2434905930 hasIssue "3" @default.
- W2434905930 hasLocation W24349059301 @default.
- W2434905930 hasOpenAccess W2434905930 @default.
- W2434905930 hasPrimaryLocation W24349059301 @default.
- W2434905930 hasRelatedWork W154415992 @default.
- W2434905930 hasRelatedWork W1969574919 @default.
- W2434905930 hasRelatedWork W1981307443 @default.
- W2434905930 hasRelatedWork W1988210607 @default.
- W2434905930 hasRelatedWork W2044853348 @default.
- W2434905930 hasRelatedWork W2069936009 @default.
- W2434905930 hasRelatedWork W207607065 @default.
- W2434905930 hasRelatedWork W2371846262 @default.
- W2434905930 hasRelatedWork W2373237830 @default.
- W2434905930 hasRelatedWork W47967586 @default.
- W2434905930 hasVolume "11" @default.
- W2434905930 isParatext "false" @default.
- W2434905930 isRetracted "false" @default.
- W2434905930 magId "2434905930" @default.
- W2434905930 workType "article" @default.