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- W2434997875 abstract "413 Objectives There is an increasing interest in PET tracers that bind specifically to tau protein since tau pathology is hypothesized to correlate to clinical symptoms in Alzheimer’s disease. The aim of this study is to evaluate tracer kinetic models for quantitative analysis and generation of parametric images of the novel tau ligand (S)-[18F]THK5117. Methods 10 subjects (5 AD, 4 MCI, 1 non-AD dementia) received a 90 min dynamic (S)-[18F]THK5117 PET scan. Arterial blood was sampled for measurement of blood activity and metabolite analysis. VOI-based analysis was performed using plasma-input models (single-tissue 1T and two-tissue 2T compartment models; plasma-input Logan) and reference tissue models (SRTM, reference Logan, and SUV ratio). Cerebellum gray matter was used as reference region. In addition to 90 min, initial 40 and 60 min data were analysed. Voxel-level analysis was performed using basis function implementations of SRTM (RPM, RPM2), reference Logan and SUVr. Regionally averaged voxel values were compared to VOI-based values from the optimal reference tissue model. Simulations were performed to assess accuracy and precision. Results Plasma-input Logan DVR-1 agreed well with 2T DVR-1 (R2=0.99, slope=0.99). SRTM BPND and reference Logan DVR-1 showed high correlation to plasma-input Logan DVR-1 (R2³0.99, slope=0.98-0.99) while SUVr-1 values overestimated binding. SRTM BPND and reference Logan DVR-1 values were not affected by a 60 min scan duration. Agreement between parametric methods and SRTM was best for reference Logan (R2=0.99, slope=1.01). Simulations showed a lower accuracy and precision for SUVr-1 values compared to other reference methods. Conclusions SRTM BPND and reference Logan DVR-1 showed high correlation to plasma-input Logan DVR-1 and robust results of VOI-based data analyses were found for scan durations of 60 min. Reference Logan was able to generate quantitative (S)-[18F]THK5117 DVR-1 parametric images with the highest accuracy and precision." @default.
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- W2434997875 date "2015-05-01" @default.
- W2434997875 modified "2023-10-15" @default.
- W2434997875 title "Tracer kinetic analysis of (S)-[18F]THK5117 as a PET tracer for tau pathology" @default.
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