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- W24350009 abstract "The use of Positron Emission Tomography (PET) to examine drug pharmacokinetics and pharmacodynamics and the relationship of these properties to the behavioral, therapeutic and toxic properties of drugs is emerging as a powerful new scientific tool (Fowler et al., 1990). PET provides a new perspective on drug research by virtue of its ability to directly assess different parameters such as absolute uptake, regional distribution, kinetics, pharmacological profile and metabolic effects of drugs in human subjects. For example, the labeled drug itself can be used to measure the absolute uptake, regional distribution and kinetics at its site of action in the body. Additionally, the labeled drug and whole body PET can be used to determine the target organs for the drug and its labeled metabolites, thus providing information on potential toxic effects as well as tissue half-lives. On the other hand, different labeled tracers can be used to assess the effects of a drug on particular physiological or functional processes. For example, with appropriate radiotracers, the effects of a drug on metabolism, neurotransmitter activity, blood flow, enzyme activity or other processes can be probed. Because of the short half-life of the positron emitters, these parameters can be assessed directly in the human body both in normal controls and in patients and serial studies can be done where a subject serves as his own control." @default.
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- W24350009 date "1993-01-01" @default.
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- W24350009 title "Positron Emission Tomography, Enzymes and Drug Research and Development" @default.
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- W24350009 doi "https://doi.org/10.1007/978-1-4684-6808-3_10" @default.
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