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- W2435014761 abstract "We show here that TPA treatment of MCF-7 cells represses estrogen receptor dependent transcriptional activity, while increasing the AP1 binding activity. These two events are probably linked, since the transcriptional activity of the estrogen receptor in these cells is repressed by overexpression of both cJun or cFos, the components of the AP1 transcripts factor. On the contrary no repression was observed after overexpression of another member of the jun family, the JunD. The repression caused by cJun or cFos may depend on partially different pathways. Our results suggest that the inhibition of TPA of the estrogen dependent growth of the MCF-7 cells is caused by over expression of cJun and cFos." @default.
- W2435014761 created "2016-06-24" @default.
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- W2435014761 date "1991-01-01" @default.
- W2435014761 modified "2023-09-25" @default.
- W2435014761 title "[Functional interaction between estrogen receptor and proto-oncogene products c-Jun and c-Fos]." @default.
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