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• W2435148066 abstract "Medical personnel accidentally exposed to blood from patients who had acute hepatitis or carried hepatitis B surface antigen (HBsAg) were assigned randomly to receive two injections one month apart of immune serum globulin containing a high titer of antibody to HBsAg (anti-HBs) (269 subjects), an intermediate titer (223 subjects), or a normal titer (265 subjects). Four months after exposure nearly 7% of recipients of normal-titer globulin or intermediate-titer globulin had developed hepatitis B, whereas no cases had appeared among recipients of high-titer globulin (P 0.30). Intercurrent infection was estimated to have accounted for only 20% of late-onset cases; 80% were thought to reflect an effect of high-titer globulin which was sufficient to delay onset but insufficient to reduce clinical severity. Many of these cases emerged in the presence of anti-HBs residual from administration of hightiter globulin, whereas no cases occurred in individuals who already possessed minimal amounts of anti-HBs at the time of exposure. The high-titer globulin was found to contain fragmented anti-HBs which may have interfered with the neutralizing activity of the large amount of unfragmented anti-HBs also present in the high-titer globulin. In any event, the lack of significant protection in the current trial means that a decision to use high-titer globulin as postexposure prophylaxis will have to rest upon the evidence of protection that has been obtained by others." @default.
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• W2435148066 date "1978-01-01" @default.
• W2435148066 modified "2023-09-23" @default.
• W2435148066 title "Hepatitis B Immune Globulin for Accidental Exposures among Medical Personnel: Final Report of a Multicenter" @default.
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