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• W2435240621 abstract "In 1981 we (1) presented evidence that the blood-brain barrier consisted of (at least) two compartments . Subsequently, Pardridge (2) took issue with our data and with our interpretation. In response, we have thoroughly reexamined our findings as well as related work in the literature (2-5). From this we have confirmed that the blood-brain barrier does consist of (at least) two compartments . We have also discovered that one of the equations in our article was in error and, consequently, that some of our comments were erroneous and require correction. In our method (6, 7), the transport rate is mathematically defined by the slope of the straight line relating the molar accumulation of the tracer amino acid, in the brain, to the time elapsed since its injection. We found the blood-brain transport rate of tyrosine (Tyr) to be constant from about 2-15 min. After injection of the enzyme inhibitor methionine sulfoximine (MSO), however , the slope of the t ranspor t l ine was seen to decrease by 30-40% along with a marked increase in the value of the intercept at zero time. In our paper (I) we sought to explain how the intercept of the t ranspor t l ine could be anything other than zero at zero time since our method measures a randomly chosen segment of a constant, ongoing process. Focusing on the data from the MSO treated animals, we concluded that there were (at least) two linear processes: one, feeding a relatively small tissue comparment whose specific activity came to equilibrium with that of the plasma earlier than 2 rain and, because of the equilibrium, appeared to drop out. The second process was assumed to feed a larger tissue compartment that did not come to equilibrium with the plasma over the" @default.
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• W2435240621 date "1986-11-01" @default.
• W2435240621 modified "2023-10-02" @default.
• W2435240621 title "Compartmentation in the bloodbrain barrier: A correction" @default.
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• W2435240621 doi "https://doi.org/10.1007/bf00965780" @default.
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