FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2435390469> ?p ?o ?g. }

• W2435390469 endingPage "5938" @default.
• W2435390469 startingPage "5929" @default.
• W2435390469 abstract "Abstract Purpose: CDK-activating kinase (CAK) is required for the regulation of the cell cycle and is a trimeric complex consisting of cyclin-dependent kinase 7 (CDK7), Cyclin H, and the accessory protein, MAT1. CDK7 also plays a critical role in regulating transcription, primarily by phosphorylating RNA polymerase II, as well as transcription factors such as estrogen receptor-α (ER). Deregulation of cell cycle and transcriptional control are general features of tumor cells, highlighting the potential for the use of CDK7 inhibitors as novel cancer therapeutics. Experimental Design: mRNA and protein expression of CDK7 and its essential cofactors cyclin H and MAT1 were evaluated in breast cancer samples to determine if their levels are altered in cancer. Immunohistochemical staining of &gt;900 breast cancers was used to determine the association with clinicopathologic features and patient outcome. Results: We show that expressions of CDK7, cyclin H, and MAT1 are all closely linked at the mRNA and protein level, and their expression is elevated in breast cancer compared with the normal breast tissue. Intriguingly, CDK7 expression was inversely proportional to tumor grade and size, and outcome analysis showed an association between CAK levels and better outcome. Moreover, CDK7 expression was positively associated with ER expression and in particular with phosphorylation of ER at serine 118, a site important for ER transcriptional activity. Conclusions: Expressions of components of the CAK complex, CDK7, MAT1, and Cyclin H are elevated in breast cancer and correlate with ER. Like ER, CDK7 expression is inversely proportional to poor prognostic factors and survival. Clin Cancer Res; 22(23); 5929–38. ©2016 AACR." @default.
• W2435390469 created "2016-06-24" @default.
• W2435390469 creator A5009776692 @default.
• W2435390469 creator A5011449034 @default.
• W2435390469 creator A5017087346 @default.
• W2435390469 creator A5019231390 @default.
• W2435390469 creator A5020838260 @default.
• W2435390469 creator A5033292960 @default.
• W2435390469 creator A5037070187 @default.
• W2435390469 creator A5037246934 @default.
• W2435390469 creator A5047833231 @default.
• W2435390469 creator A5051064466 @default.
• W2435390469 creator A5051462785 @default.
• W2435390469 creator A5059145284 @default.
• W2435390469 creator A5064931519 @default.
• W2435390469 creator A5066555489 @default.
• W2435390469 creator A5066580354 @default.
• W2435390469 creator A5068173924 @default.
• W2435390469 creator A5070453729 @default.
• W2435390469 creator A5075105813 @default.
• W2435390469 creator A5076148205 @default.
• W2435390469 creator A5089112122 @default.
• W2435390469 creator A5089173433 @default.
• W2435390469 creator A5090076650 @default.
• W2435390469 creator A5090506275 @default.
• W2435390469 date "2016-11-30" @default.
• W2435390469 modified "2023-10-17" @default.
• W2435390469 title "Expression of CDK7, Cyclin H, and MAT1 Is Elevated in Breast Cancer and Is Prognostic in Estrogen Receptor–Positive Breast Cancer" @default.
• W2435390469 cites W1875122842 @default.
• W2435390469 cites W1958364339 @default.
• W2435390469 cites W1970755773 @default.
• W2435390469 cites W1971626947 @default.
• W2435390469 cites W1974334424 @default.
• W2435390469 cites W1982378557 @default.
• W2435390469 cites W1987835482 @default.
• W2435390469 cites W1991054314 @default.
• W2435390469 cites W1996741456 @default.
• W2435390469 cites W1998187004 @default.
• W2435390469 cites W2005895632 @default.
• W2435390469 cites W2007618242 @default.
• W2435390469 cites W2015766045 @default.
• W2435390469 cites W2030738969 @default.
• W2435390469 cites W2038006194 @default.
• W2435390469 cites W2043074724 @default.
• W2435390469 cites W2046024621 @default.
• W2435390469 cites W2047446484 @default.
• W2435390469 cites W2059272061 @default.
• W2435390469 cites W2060334131 @default.
• W2435390469 cites W2061543344 @default.
• W2435390469 cites W2066784889 @default.
• W2435390469 cites W2067873262 @default.
• W2435390469 cites W2070392447 @default.
• W2435390469 cites W2072684537 @default.
• W2435390469 cites W2075152619 @default.
• W2435390469 cites W2080217598 @default.
• W2435390469 cites W2084495041 @default.
• W2435390469 cites W2085546128 @default.
• W2435390469 cites W2100467443 @default.
• W2435390469 cites W2103989098 @default.
• W2435390469 cites W2107277218 @default.
• W2435390469 cites W2120856107 @default.
• W2435390469 cites W2125772206 @default.
• W2435390469 cites W2133650808 @default.
• W2435390469 cites W2143238584 @default.
• W2435390469 cites W2144790402 @default.
• W2435390469 cites W2150344507 @default.
• W2435390469 cites W2151995827 @default.
• W2435390469 cites W2152441047 @default.
• W2435390469 cites W2153206714 @default.
• W2435390469 cites W2162765338 @default.
• W2435390469 cites W2170846478 @default.
• W2435390469 cites W2171613528 @default.
• W2435390469 cites W4231356616 @default.
• W2435390469 doi "https://doi.org/10.1158/1078-0432.ccr-15-1104" @default.
• W2435390469 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5293170" @default.
• W2435390469 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27301701" @default.
• W2435390469 hasPublicationYear "2016" @default.
• W2435390469 type Work @default.
• W2435390469 sameAs 2435390469 @default.
• W2435390469 citedByCount "61" @default.
• W2435390469 countsByYear W24353904692017 @default.
• W2435390469 countsByYear W24353904692018 @default.
• W2435390469 countsByYear W24353904692019 @default.
• W2435390469 countsByYear W24353904692020 @default.
• W2435390469 countsByYear W24353904692021 @default.
• W2435390469 countsByYear W24353904692022 @default.
• W2435390469 countsByYear W24353904692023 @default.
• W2435390469 crossrefType "journal-article" @default.
• W2435390469 hasAuthorship W2435390469A5009776692 @default.
• W2435390469 hasAuthorship W2435390469A5011449034 @default.
• W2435390469 hasAuthorship W2435390469A5017087346 @default.
• W2435390469 hasAuthorship W2435390469A5019231390 @default.
• W2435390469 hasAuthorship W2435390469A5020838260 @default.
• W2435390469 hasAuthorship W2435390469A5033292960 @default.
• W2435390469 hasAuthorship W2435390469A5037070187 @default.
• W2435390469 hasAuthorship W2435390469A5037246934 @default.
• W2435390469 hasAuthorship W2435390469A5047833231 @default.
• W2435390469 hasAuthorship W2435390469A5051064466 @default.

• next