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- W2435551379 abstract "Objective: To study the protective effects of salidroside on injury induced by hypoxia /hypoglycemia in cultured SH-SY5Y cell. Method: Apoptosis and intracellular free calcium concentration([Ca 2+ ]i) were measured by flow cytometry, morphological changes and neuronal necrosis were observed with fluorescence microscope, and the lactic dehydrogenate (LDH) release was measured by LDH kits. Result: Hypoxia /hypoglycemia cultures for 2 hours induced neuronal apoptosis and necrosis. They were 18.59%( P 0.01) and 4.94%( P 0.01) respectively. There were morphological changes including chromatin condensation, nuclear fragmentation and formed apoptotic bodies after exposed to hypoxia /hypoglycemia for 2,4,6,12 hours. After 2 hours of hypoxia /hypoglycemia, neuronal [Ca 2+ ]i and the release of LDH were significantly increased .They were 8.46 nmol/L ( P 0.01) and 16.59%( P 0.01) respectively. The effects were enhanced with the extending time of hypoxia/hypoglycemia. Salidroside might have significantly decreased the percentage of neuronal apoptosis and necrosis, reduced neuronal [Ca 2+ ]i and the release of LDH. The effects of salidroside were strengthened with the increasing of Salidroside dosage. Conclusion: Salidroside has effect of anti-neuronal apoptosis. This effect might be related to its function of decreasing intracellular free calcium concentration." @default.
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- W2435551379 date "2004-05-01" @default.
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- W2435551379 title "[Protective effects of salidroside on injury induced by hypoxia/hypoglycemia in cultured neurons]." @default.
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