Matches in SemOpenAlex for { <https://semopenalex.org/work/W2435590410> ?p ?o ?g. }
Showing items 1 to 71 of
71
with 100 items per page.
- W2435590410 endingPage "14" @default.
- W2435590410 startingPage "407" @default.
- W2435590410 abstract "The aims of this study were: (i) to establish a reliable model for the study of cystic endometrial hyperplasia in ovariectomized bitches; and (ii) to assess the roles of oestrogen and progesterone in the pathogenesis of irritant-induced cystic endometrial hyperplasia. Greyhound bitches (n = 15) were ovariectomized and divided into five groups (n = 3 per group). After 3-4 weeks, oestradiol benzoate (0.6-4.8 micrograms kg-1, i.m.) was administered twice a day for 12 days to the bitches in group 1, followed by progesterone (0.2-1.8 mg kg-1, i.m.) twice a day for 30-33 days. These dosages were chosen to mimic the plasma hormone concentrations of a normal oestrous cycle. A silk suture was inserted by laparotomy into the left uterine horn 12 days into the simulated dioestrus (determined by vaginal cytology) and necropsy was performed after a further 12 days. For groups 2-5, the silk suture was positioned at ovariectomy. After a further 3-4 weeks, these bitches were treated with progesterone (group 2: 1.8 mg kg-1 i.m. twice a day), oestradiol benzoate (group 3: 0.6-4.8 micrograms kg-1 i.m. twice a day), oestradiol benzoate and progesterone together (group 4: previous dosages) or vehicle (group 5). Necropsies were performed after 12-13 days of treatment. Cystic endometrial hyperplasia was induced in the suture-containing uterine horns of all bitches in groups 1 and 4, and in two bitches in group 2. Cystic endometrial hyperplasia did not develop in any control (no suture) uterine horns, or in either uterine horn of the bitches treated with either oestradiol only or vehicle. These results indicate that progesterone is necessary for the development of irritant-induced cystic endometrial hyperplasia and that oestradiol potentiates the effects of progesterone. The protocol used for bitches in group 1 would be a suitable model for further studies of the pathogenesis of cystic endometrial hyperplasia." @default.
- W2435590410 created "2016-06-24" @default.
- W2435590410 creator A5041725242 @default.
- W2435590410 creator A5070420743 @default.
- W2435590410 creator A5088067337 @default.
- W2435590410 date "2001-01-01" @default.
- W2435590410 modified "2023-09-23" @default.
- W2435590410 title "A model for the study of cystic endometrial hyperplasia in bitches." @default.
- W2435590410 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11787183" @default.
- W2435590410 hasPublicationYear "2001" @default.
- W2435590410 type Work @default.
- W2435590410 sameAs 2435590410 @default.
- W2435590410 citedByCount "4" @default.
- W2435590410 countsByYear W24355904102013 @default.
- W2435590410 countsByYear W24355904102015 @default.
- W2435590410 crossrefType "journal-article" @default.
- W2435590410 hasAuthorship W2435590410A5041725242 @default.
- W2435590410 hasAuthorship W2435590410A5070420743 @default.
- W2435590410 hasAuthorship W2435590410A5088067337 @default.
- W2435590410 hasConcept C126322002 @default.
- W2435590410 hasConcept C134018914 @default.
- W2435590410 hasConcept C141071460 @default.
- W2435590410 hasConcept C162156334 @default.
- W2435590410 hasConcept C1998276 @default.
- W2435590410 hasConcept C2777164284 @default.
- W2435590410 hasConcept C2777562237 @default.
- W2435590410 hasConcept C2777689261 @default.
- W2435590410 hasConcept C2778227567 @default.
- W2435590410 hasConcept C2778506572 @default.
- W2435590410 hasConcept C2779066055 @default.
- W2435590410 hasConcept C2779494336 @default.
- W2435590410 hasConcept C2779742232 @default.
- W2435590410 hasConcept C2780778865 @default.
- W2435590410 hasConcept C71924100 @default.
- W2435590410 hasConcept C8264082 @default.
- W2435590410 hasConceptScore W2435590410C126322002 @default.
- W2435590410 hasConceptScore W2435590410C134018914 @default.
- W2435590410 hasConceptScore W2435590410C141071460 @default.
- W2435590410 hasConceptScore W2435590410C162156334 @default.
- W2435590410 hasConceptScore W2435590410C1998276 @default.
- W2435590410 hasConceptScore W2435590410C2777164284 @default.
- W2435590410 hasConceptScore W2435590410C2777562237 @default.
- W2435590410 hasConceptScore W2435590410C2777689261 @default.
- W2435590410 hasConceptScore W2435590410C2778227567 @default.
- W2435590410 hasConceptScore W2435590410C2778506572 @default.
- W2435590410 hasConceptScore W2435590410C2779066055 @default.
- W2435590410 hasConceptScore W2435590410C2779494336 @default.
- W2435590410 hasConceptScore W2435590410C2779742232 @default.
- W2435590410 hasConceptScore W2435590410C2780778865 @default.
- W2435590410 hasConceptScore W2435590410C71924100 @default.
- W2435590410 hasConceptScore W2435590410C8264082 @default.
- W2435590410 hasLocation W24355904101 @default.
- W2435590410 hasOpenAccess W2435590410 @default.
- W2435590410 hasPrimaryLocation W24355904101 @default.
- W2435590410 hasRelatedWork W1965313154 @default.
- W2435590410 hasRelatedWork W1974913662 @default.
- W2435590410 hasRelatedWork W1985743452 @default.
- W2435590410 hasRelatedWork W2021677673 @default.
- W2435590410 hasRelatedWork W2072535254 @default.
- W2435590410 hasRelatedWork W2090167121 @default.
- W2435590410 hasRelatedWork W2142720468 @default.
- W2435590410 hasRelatedWork W2368832531 @default.
- W2435590410 hasRelatedWork W2405347771 @default.
- W2435590410 hasRelatedWork W2435590410 @default.
- W2435590410 hasVolume "57" @default.
- W2435590410 isParatext "false" @default.
- W2435590410 isRetracted "false" @default.
- W2435590410 magId "2435590410" @default.
- W2435590410 workType "article" @default.