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- W2435632533 abstract "A general description of the folic acid cycle and associate reactions of thymidilate, purines, methionine and serine biosyntheses is presented as a system of differential equations. The concrete models of this reaction complex as well as methotrexate transport into the leukemia L 1210 and Ehrlich ascite tumour cells and the dynamic inhibition of the target enzyme--dihydrofolate reductase--by methotrexate have been described and investigated. The adequacy of mathematical models to the experimental data has been demonstrated." @default.
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- W2435632533 date "1980-01-01" @default.
- W2435632533 modified "2023-09-23" @default.
- W2435632533 title "[Mathematical description and study of the folic acid cycle reactions]." @default.
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