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• W2435826075 abstract "Early-life sleep deprivation (ESD) is a serious condition with severe metabolic sequelae. The pineal hor- mone melatonin plays an important role in homeostatic regulation of metabolic function. Considering norepi- nephrine-mediated Ca 2? influx and subsequent protein kinase A (PKA) activation is responsible for downstream cAMP-response element-binding protein (CREB) phos- phorylation and melatonin biosynthesis, the present study determined whether Ca 2? expression, together with the molecular machinery participated in melatonin production would significantly alter after ESD. Weaning rats subjected to chronic ESD and maintained naturally (light:dark cycle = 12:12) to adulthood were processed for time-of- flight secondary ion mass spectrometry, immunoblotting, immunohistochemistry together with spectrometric assay to detect the Ca 2? signaling, adrenoreceptors, PKA, phosphorylated CREB (pCREB) as well as the serum level of melatonin, respectively. Pineal bio-energetics and met- abolic function were determined by measuring the cyto- chrome oxidase activity and serum level of glucose, triglyceride, insulin, high- and low-density lipoproteins, respectively. Results indicated that in normal rats, strong Ca 2? signaling along with intense adrenoreceptors, PKA, and pCREB activities were all detected in pinealocytes. Enhanced Ca 2? imaging and signaling pathway corre- sponded well with intact bio-energetics, normal melatonin production and metabolic activity. However, following ESD, not only Ca 2? but also pineal signaling activities were all significantly decreased. Blood analysis showed reduced melatonin level and impaired metabolic function after ESD. As depressed Ca 2? -mediated signaling pathway and melatonin biosynthesis are positively correlated with the development of metabolic dysfunction, supplementary use of melatonin in childhood may thus serve as a practical way to prevent or counteract the ESD-induced metabolic deficiency." @default.
• W2435826075 created "2016-06-24" @default.
• W2435826075 creator A5029922422 @default.
• W2435826075 date "2015-01-01" @default.
• W2435826075 modified "2023-09-26" @default.
• W2435826075 title "Early-life sleep deprivation persistently depresses melatonin production and bio-energetics of the pineal gland: potential implications for the development of metabolic deficiency" @default.
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