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• W2435876680 abstract "Abstract Aerobic glycolysis, termed “the Warburg Effect”, supports cell proliferation, and glucose deprivation directly elicits necrosis or shifts stimuli-induced apoptosis to necrosis. However, how glucose metabolism regulates cell survival or death choice remains largely unclear. Here we use our recently developed method to monitor in real-time cellular apoptosis and necrosis, and uncover a metabolic homeostasis linked to cell death control. We show that glucose metabolism is the major source to maintain both intracellular and extracellular proton homeostasis. Glucose deficiency leads to lack of proton provision, which provokes a compensatory lysosomal proton efflux and resultant increased lysosomal pH. This lysosomal alkalinization can trigger necrosis. Furthermore, artificial proton supplement enables cells to survive glucose deprivation. Taken together, our results reveal a critical role of glucose metabolism in maintaining cellular microenvironment, and provide a better understanding of the essential requirement of aerobic glycolysis for proliferating cells whose active anabolism consumes a great many protons." @default.
• W2435876680 created "2016-06-24" @default.
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• W2435876680 date "2016-06-13" @default.
• W2435876680 modified "2023-10-18" @default.
• W2435876680 title "Maintaining proton homeostasis is an essential role of glucose metabolism in cell survival" @default.
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• W2435876680 doi "https://doi.org/10.1101/058594" @default.
• W2435876680 hasPublicationYear "2016" @default.
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