Matches in SemOpenAlex for { <https://semopenalex.org/work/W2436189875> ?p ?o ?g. }
- W2436189875 endingPage "153" @default.
- W2436189875 startingPage "131" @default.
- W2436189875 abstract "The hepatitis B virus (HBV) genome encodes four proteins, i.e., DNA polymerase, surface protein, X, and core proteins. HBV undergoes different selective pressures for drug resistance and immune/vaccine escape and mutations are common for the HBV proteins. We here collected all the reported amino acid mutations happened in these four HBV proteins and studied their patterns. The relationship between the mutations and epitopic functions are investigated with bioinformatics tools, based on their sequence information. Some interesting results are observed for the mutation patterns, such as we found the serine and threonine are both for frequently mutated residues and mutant residues, while the tryptophan and methionine have low mutability. The results provide important information for the understanding of the molecular mechanism of virus evolution and therefore will facilitate the future rational design of HBV vaccines or drugs." @default.
- W2436189875 created "2016-06-24" @default.
- W2436189875 creator A5008447913 @default.
- W2436189875 creator A5009559952 @default.
- W2436189875 creator A5037677450 @default.
- W2436189875 creator A5067618472 @default.
- W2436189875 creator A5081095213 @default.
- W2436189875 date "2015-01-01" @default.
- W2436189875 modified "2023-09-25" @default.
- W2436189875 title "Understanding Amino Acid Mutations in Hepatitis B Virus Proteins for Rational Design of Vaccines and Drugs" @default.
- W2436189875 cites W1497815517 @default.
- W2436189875 cites W1508758346 @default.
- W2436189875 cites W1596377987 @default.
- W2436189875 cites W1972621502 @default.
- W2436189875 cites W1976489901 @default.
- W2436189875 cites W1981769964 @default.
- W2436189875 cites W1994048581 @default.
- W2436189875 cites W1997851414 @default.
- W2436189875 cites W2003274125 @default.
- W2436189875 cites W2019661447 @default.
- W2436189875 cites W2022484447 @default.
- W2436189875 cites W2024546205 @default.
- W2436189875 cites W2028147409 @default.
- W2436189875 cites W2032046359 @default.
- W2436189875 cites W2043071727 @default.
- W2436189875 cites W2053707749 @default.
- W2436189875 cites W2062018073 @default.
- W2436189875 cites W2088377308 @default.
- W2436189875 cites W2088810496 @default.
- W2436189875 cites W2089027294 @default.
- W2436189875 cites W2098639665 @default.
- W2436189875 cites W2100316154 @default.
- W2436189875 cites W2104389844 @default.
- W2436189875 cites W2104969243 @default.
- W2436189875 cites W2106159290 @default.
- W2436189875 cites W2118943119 @default.
- W2436189875 cites W2123685182 @default.
- W2436189875 cites W2128433194 @default.
- W2436189875 cites W2137575262 @default.
- W2436189875 cites W2143282878 @default.
- W2436189875 cites W2144166466 @default.
- W2436189875 cites W2150537020 @default.
- W2436189875 cites W2157151381 @default.
- W2436189875 cites W2158899863 @default.
- W2436189875 cites W2160397907 @default.
- W2436189875 cites W2163881579 @default.
- W2436189875 cites W2165782847 @default.
- W2436189875 cites W2167744756 @default.
- W2436189875 cites W2180512905 @default.
- W2436189875 cites W2464003550 @default.
- W2436189875 cites W4238591974 @default.
- W2436189875 cites W2072668334 @default.
- W2436189875 doi "https://doi.org/10.1016/bs.apcsb.2015.03.006" @default.
- W2436189875 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26067819" @default.
- W2436189875 hasPublicationYear "2015" @default.
- W2436189875 type Work @default.
- W2436189875 sameAs 2436189875 @default.
- W2436189875 citedByCount "5" @default.
- W2436189875 countsByYear W24361898752016 @default.
- W2436189875 countsByYear W24361898752017 @default.
- W2436189875 countsByYear W24361898752020 @default.
- W2436189875 countsByYear W24361898752022 @default.
- W2436189875 countsByYear W24361898752023 @default.
- W2436189875 crossrefType "book-chapter" @default.
- W2436189875 hasAuthorship W2436189875A5008447913 @default.
- W2436189875 hasAuthorship W2436189875A5009559952 @default.
- W2436189875 hasAuthorship W2436189875A5037677450 @default.
- W2436189875 hasAuthorship W2436189875A5067618472 @default.
- W2436189875 hasAuthorship W2436189875A5081095213 @default.
- W2436189875 hasConcept C104317684 @default.
- W2436189875 hasConcept C141231307 @default.
- W2436189875 hasConcept C143065580 @default.
- W2436189875 hasConcept C159047783 @default.
- W2436189875 hasConcept C167625842 @default.
- W2436189875 hasConcept C2522874641 @default.
- W2436189875 hasConcept C2777382497 @default.
- W2436189875 hasConcept C2780593183 @default.
- W2436189875 hasConcept C2780912031 @default.
- W2436189875 hasConcept C2994376932 @default.
- W2436189875 hasConcept C501734568 @default.
- W2436189875 hasConcept C515207424 @default.
- W2436189875 hasConcept C53105671 @default.
- W2436189875 hasConcept C54355233 @default.
- W2436189875 hasConcept C552990157 @default.
- W2436189875 hasConcept C82381507 @default.
- W2436189875 hasConcept C86803240 @default.
- W2436189875 hasConceptScore W2436189875C104317684 @default.
- W2436189875 hasConceptScore W2436189875C141231307 @default.
- W2436189875 hasConceptScore W2436189875C143065580 @default.
- W2436189875 hasConceptScore W2436189875C159047783 @default.
- W2436189875 hasConceptScore W2436189875C167625842 @default.
- W2436189875 hasConceptScore W2436189875C2522874641 @default.
- W2436189875 hasConceptScore W2436189875C2777382497 @default.
- W2436189875 hasConceptScore W2436189875C2780593183 @default.
- W2436189875 hasConceptScore W2436189875C2780912031 @default.
- W2436189875 hasConceptScore W2436189875C2994376932 @default.
- W2436189875 hasConceptScore W2436189875C501734568 @default.
- W2436189875 hasConceptScore W2436189875C515207424 @default.