Matches in SemOpenAlex for { <https://semopenalex.org/work/W243623712> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W243623712 abstract "Abstract During the period from January 1970 until December 1973, therapy was started in 41 previously untreated adolescents and adults with acute lymphoblastic leukemia. Induction therapy was started with vincristine and prednisone in all patients, resulting in complete remission in 19 and death due to infection during the first month in one case. After 3 wk on these two drugs, the addition of daunorubicin was required in the remaining 21 patients. Fifteen of these obtained remission, one died during induction therapy, and five patients were unresponsive to this therapy, as well as to all subsequent induction schemes. The overall remission rate was 83%. Significantly higher initial leukocyte counts were found in the group treated with vincristine, prednisone, and daunorubicin. Meningeal leukemia prophylaxis, by either periodic methotrexate injections given intrathecally or a combination of cranial irradiation and intrathecally administrated methotrexate, was administered in 29 therapy responders. The median duration of complete remission obtained with various maintenance therapy schemes was 13 mo. No differences were seen in the results obtained in patients between 14 and 20 yr of age and older patients. Twenty-two patients relapsed within 2–37 mo. Relapses were confined to the central nervous system in two cases, to the bone marrow in 18, and to the bone marrow and CNS simultaneously in two. A second remission was obtained in 17 cases (77%). The median survival time of the whole group was 27 mo, as compared with 32 mo for therapy responders and 7 mo for the nonresponders. The percentage and duration of remission and the survival time in our group of adolescents and adults were comparable to those currently being achieved in other centers, but not as good as those reported for children treated with the same protocol." @default.
- W243623712 created "2016-06-24" @default.
- W243623712 creator A5036388936 @default.
- W243623712 creator A5045159675 @default.
- W243623712 creator A5055745584 @default.
- W243623712 creator A5057603532 @default.
- W243623712 date "1975-12-01" @default.
- W243623712 modified "2023-09-27" @default.
- W243623712 title "Treatment of acute lymphoblastic leukemia in adolescents and a-dults: A retrospective study of 41 patients (1970-1973)" @default.
- W243623712 cites W1563811194 @default.
- W243623712 cites W1830321071 @default.
- W243623712 cites W1966147272 @default.
- W243623712 cites W1990399282 @default.
- W243623712 cites W2000198236 @default.
- W243623712 cites W2013324152 @default.
- W243623712 cites W2013724544 @default.
- W243623712 cites W2096587673 @default.
- W243623712 cites W2332336320 @default.
- W243623712 cites W2397573456 @default.
- W243623712 cites W2414653645 @default.
- W243623712 cites W2417673143 @default.
- W243623712 cites W2424092976 @default.
- W243623712 cites W2471053194 @default.
- W243623712 cites W2472670777 @default.
- W243623712 doi "https://doi.org/10.1182/blood.v46.6.823.823" @default.
- W243623712 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1060469" @default.
- W243623712 hasPublicationYear "1975" @default.
- W243623712 type Work @default.
- W243623712 sameAs 243623712 @default.
- W243623712 citedByCount "55" @default.
- W243623712 countsByYear W2436237122013 @default.
- W243623712 crossrefType "journal-article" @default.
- W243623712 hasAuthorship W243623712A5036388936 @default.
- W243623712 hasAuthorship W243623712A5045159675 @default.
- W243623712 hasAuthorship W243623712A5055745584 @default.
- W243623712 hasAuthorship W243623712A5057603532 @default.
- W243623712 hasBestOaLocation W2436237121 @default.
- W243623712 hasConcept C126322002 @default.
- W243623712 hasConcept C141071460 @default.
- W243623712 hasConcept C2776694085 @default.
- W243623712 hasConcept C2776755627 @default.
- W243623712 hasConcept C2778283404 @default.
- W243623712 hasConcept C2778461978 @default.
- W243623712 hasConcept C2778720950 @default.
- W243623712 hasConcept C2779429289 @default.
- W243623712 hasConcept C2780007613 @default.
- W243623712 hasConcept C2781021840 @default.
- W243623712 hasConcept C2781059491 @default.
- W243623712 hasConcept C2781107101 @default.
- W243623712 hasConcept C2909962599 @default.
- W243623712 hasConcept C3018657049 @default.
- W243623712 hasConcept C71924100 @default.
- W243623712 hasConcept C90924648 @default.
- W243623712 hasConceptScore W243623712C126322002 @default.
- W243623712 hasConceptScore W243623712C141071460 @default.
- W243623712 hasConceptScore W243623712C2776694085 @default.
- W243623712 hasConceptScore W243623712C2776755627 @default.
- W243623712 hasConceptScore W243623712C2778283404 @default.
- W243623712 hasConceptScore W243623712C2778461978 @default.
- W243623712 hasConceptScore W243623712C2778720950 @default.
- W243623712 hasConceptScore W243623712C2779429289 @default.
- W243623712 hasConceptScore W243623712C2780007613 @default.
- W243623712 hasConceptScore W243623712C2781021840 @default.
- W243623712 hasConceptScore W243623712C2781059491 @default.
- W243623712 hasConceptScore W243623712C2781107101 @default.
- W243623712 hasConceptScore W243623712C2909962599 @default.
- W243623712 hasConceptScore W243623712C3018657049 @default.
- W243623712 hasConceptScore W243623712C71924100 @default.
- W243623712 hasConceptScore W243623712C90924648 @default.
- W243623712 hasLocation W2436237121 @default.
- W243623712 hasOpenAccess W243623712 @default.
- W243623712 hasPrimaryLocation W2436237121 @default.
- W243623712 hasRelatedWork W1491154431 @default.
- W243623712 hasRelatedWork W1963982518 @default.
- W243623712 hasRelatedWork W1969259073 @default.
- W243623712 hasRelatedWork W1986023479 @default.
- W243623712 hasRelatedWork W1991216872 @default.
- W243623712 hasRelatedWork W1996462672 @default.
- W243623712 hasRelatedWork W1998323651 @default.
- W243623712 hasRelatedWork W2013324152 @default.
- W243623712 hasRelatedWork W2018413926 @default.
- W243623712 hasRelatedWork W2027262006 @default.
- W243623712 hasRelatedWork W2044988940 @default.
- W243623712 hasRelatedWork W2076426515 @default.
- W243623712 hasRelatedWork W2080811183 @default.
- W243623712 hasRelatedWork W2096587673 @default.
- W243623712 hasRelatedWork W2097024390 @default.
- W243623712 hasRelatedWork W2218795077 @default.
- W243623712 hasRelatedWork W2237674527 @default.
- W243623712 hasRelatedWork W2285218518 @default.
- W243623712 hasRelatedWork W2294354802 @default.
- W243623712 hasRelatedWork W2414923675 @default.
- W243623712 isParatext "false" @default.
- W243623712 isRetracted "false" @default.
- W243623712 magId "243623712" @default.
- W243623712 workType "article" @default.