FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2436260080> ?p ?o ?g. }

• W2436260080 endingPage "147032031665500" @default.
• W2436260080 startingPage "147032031665500" @default.
• W2436260080 abstract "Hypothesis: Previous studies provide links between the nuclear factor of activated T lymphocytes (NFAT) signalling pathway and the development of hypertension. Our preliminary studies indicate that telmisartan can block Kv1.3 potassium channels and effectively inhibit potassium current densities, along with Kv1.3 mRNA and protein expression levels. This paper aims to investigate whether telmisartan has an inhibitory effect on the NFAT signalling pathway after activation and proliferation of peripheral blood T lymphocytes in Kazakh patients with essential hypertension (EH) from Xinjiang, China. Materials and methods: T lymphocytes were isolated using the immunomagnetic cell sorting method (MACS). The mRNA expression of NFATc1, IL-6 and TNF-α was measured by quantitative polymerase chain reaction (qRT-PCR) and relative protein levels were evaluated by Western blot. T cell samples from 50 hypertensive Kazakh patients from Xinjiang were randomly divided into control, telmisartan, cyclosporin A (CsA), VIVIT, and 4-aminopytidine (4-AP) groups. Peripheral blood T lymphocytes were first activated and proliferated in vitro, then incubated for 48 h under different treatment conditions before determination of protein and mRNA expression of NFATc1, IL-6, and TNF-α by Western blot and qRT-PCR analyses, respectively. Results: There were no significant differences in cardiovascular risk factors among the patients with samples assigned to the five groups ( p > 0.05). Expression of NFATc1, IL-6, and TNF-α mRNA and protein was significantly reduced in T lymphocytes in all treatment groups (telmisartan, CsA, VIVIT, and 4-AP) compared with controls. Conclusions: Antihypertensive function and inhibitory effects of telmisartan on the T lymphocyte NFAT signalling pathway are unlikely to affect the normal immune function of hypertensive patients. Telmisartan may exert anti-inflammatory effects by inhibition of the NFAT signalling pathway in the T lymphocytes of hypertensive patients." @default.
• W2436260080 created "2016-06-24" @default.
• W2436260080 creator A5020937345 @default.
• W2436260080 creator A5054551943 @default.
• W2436260080 creator A5087019032 @default.
• W2436260080 date "2016-04-01" @default.
• W2436260080 modified "2023-10-17" @default.
• W2436260080 title "The effects of telmisartan on the nuclear factor of activated T lymphocytes signalling pathway in hypertensive patients" @default.
• W2436260080 cites W1495055806 @default.
• W2436260080 cites W1965462878 @default.
• W2436260080 cites W1983675868 @default.
• W2436260080 cites W1995866677 @default.
• W2436260080 cites W2000596634 @default.
• W2436260080 cites W2018775174 @default.
• W2436260080 cites W2031460879 @default.
• W2436260080 cites W2034845795 @default.
• W2436260080 cites W2038844856 @default.
• W2436260080 cites W2043040664 @default.
• W2436260080 cites W2065014879 @default.
• W2436260080 cites W2069112544 @default.
• W2436260080 cites W2070674399 @default.
• W2436260080 cites W2077887669 @default.
• W2436260080 cites W2085584630 @default.
• W2436260080 cites W2095434115 @default.
• W2436260080 cites W2101232241 @default.
• W2436260080 cites W2117185007 @default.
• W2436260080 cites W2120581373 @default.
• W2436260080 cites W2132194740 @default.
• W2436260080 cites W2134362683 @default.
• W2436260080 cites W2141269884 @default.
• W2436260080 cites W2152043519 @default.
• W2436260080 cites W2155729941 @default.
• W2436260080 cites W2163982634 @default.
• W2436260080 cites W2414364793 @default.
• W2436260080 cites W2415455910 @default.
• W2436260080 cites W2475261460 @default.
• W2436260080 doi "https://doi.org/10.1177/1470320316655005" @default.
• W2436260080 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5843869" @default.
• W2436260080 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27317303" @default.
• W2436260080 hasPublicationYear "2016" @default.
• W2436260080 type Work @default.
• W2436260080 sameAs 2436260080 @default.
• W2436260080 citedByCount "3" @default.
• W2436260080 countsByYear W24362600802021 @default.
• W2436260080 countsByYear W24362600802022 @default.
• W2436260080 crossrefType "journal-article" @default.
• W2436260080 hasAuthorship W2436260080A5020937345 @default.
• W2436260080 hasAuthorship W2436260080A5054551943 @default.
• W2436260080 hasAuthorship W2436260080A5087019032 @default.
• W2436260080 hasBestOaLocation W24362600801 @default.
• W2436260080 hasConcept C104317684 @default.
• W2436260080 hasConcept C105580179 @default.
• W2436260080 hasConcept C126322002 @default.
• W2436260080 hasConcept C128057223 @default.
• W2436260080 hasConcept C134018914 @default.
• W2436260080 hasConcept C153911025 @default.
• W2436260080 hasConcept C185592680 @default.
• W2436260080 hasConcept C189938988 @default.
• W2436260080 hasConcept C203014093 @default.
• W2436260080 hasConcept C2776090121 @default.
• W2436260080 hasConcept C2776415932 @default.
• W2436260080 hasConcept C2779716603 @default.
• W2436260080 hasConcept C2911091166 @default.
• W2436260080 hasConcept C55493867 @default.
• W2436260080 hasConcept C71924100 @default.
• W2436260080 hasConcept C84393581 @default.
• W2436260080 hasConcept C86803240 @default.
• W2436260080 hasConcept C8891405 @default.
• W2436260080 hasConcept C98274493 @default.
• W2436260080 hasConceptScore W2436260080C104317684 @default.
• W2436260080 hasConceptScore W2436260080C105580179 @default.
• W2436260080 hasConceptScore W2436260080C126322002 @default.
• W2436260080 hasConceptScore W2436260080C128057223 @default.
• W2436260080 hasConceptScore W2436260080C134018914 @default.
• W2436260080 hasConceptScore W2436260080C153911025 @default.
• W2436260080 hasConceptScore W2436260080C185592680 @default.
• W2436260080 hasConceptScore W2436260080C189938988 @default.
• W2436260080 hasConceptScore W2436260080C203014093 @default.
• W2436260080 hasConceptScore W2436260080C2776090121 @default.
• W2436260080 hasConceptScore W2436260080C2776415932 @default.
• W2436260080 hasConceptScore W2436260080C2779716603 @default.
• W2436260080 hasConceptScore W2436260080C2911091166 @default.
• W2436260080 hasConceptScore W2436260080C55493867 @default.
• W2436260080 hasConceptScore W2436260080C71924100 @default.
• W2436260080 hasConceptScore W2436260080C84393581 @default.
• W2436260080 hasConceptScore W2436260080C86803240 @default.
• W2436260080 hasConceptScore W2436260080C8891405 @default.
• W2436260080 hasConceptScore W2436260080C98274493 @default.
• W2436260080 hasIssue "2" @default.
• W2436260080 hasLocation W24362600801 @default.
• W2436260080 hasLocation W24362600802 @default.
• W2436260080 hasLocation W24362600803 @default.
• W2436260080 hasLocation W24362600804 @default.
• W2436260080 hasLocation W24362600805 @default.
• W2436260080 hasOpenAccess W2436260080 @default.
• W2436260080 hasPrimaryLocation W24362600801 @default.
• W2436260080 hasRelatedWork W1978332820 @default.
• W2436260080 hasRelatedWork W1980194808 @default.

• next