FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2436309544> ?p ?o ?g. }

• W2436309544 endingPage "1402" @default.
• W2436309544 startingPage "1392" @default.
• W2436309544 abstract "Relaxin is a hormone that has been considered as a potential therapy for patients with fibrotic diseases.To gauge the potential efficacy of relaxin-based therapies in idiopathic pulmonary fibrosis (IPF), we studied gene expression for relaxin/insulin-like family peptide receptor 1 (RXFP1) in IPF lungs and controls.We analyzed gene expression data obtained from the Lung Tissue Research Consortium and correlated RXFP1 gene expression data with cross-sectional clinical and demographic data. We also employed ex vivo donor and IPF lung fibroblasts to test RXFP1 expression in vitro. We tested CGEN25009, a relaxin-like peptide, in lung fibroblasts and in bleomycin injury.We found that RXFP1 is significantly decreased in IPF. In patients with IPF, the magnitude of RXFP1 gene expression correlated directly with diffusing capacity of the lung for carbon monoxide (P < 0.0001). Significantly less RXFP1 was detected in vitro in IPF fibroblasts than in donor controls. Transforming growth factor-β decreased RXFP1 in both donor and IPF lung fibroblasts. CGEN25009 was effective at decreasing bleomycin-induced, acid-soluble collagen deposition in vivo. The relaxin-like actions of CGEN25009 were abrogated by RXFP1 silencing in vitro, and, in comparison with donor lung fibroblasts, IPF lung fibroblasts exhibited decreased sensitivity to the relaxin-like effects of CGEN25009.IPF is characterized by the loss of RXFP1 expression. RXFP1 expression is directly associated with pulmonary function in patients with IPF. The relaxin-like effects of CGEN25009 in vitro are dependent on expression of RXFP1. Our data suggest that patients with IPF with the highest RXFP1 expression would be predicted to be most sensitive to relaxin-based therapies." @default.
• W2436309544 created "2016-06-24" @default.
• W2436309544 creator A5026015210 @default.
• W2436309544 creator A5027286465 @default.
• W2436309544 creator A5035257973 @default.
• W2436309544 creator A5040323862 @default.
• W2436309544 creator A5050693307 @default.
• W2436309544 creator A5051655241 @default.
• W2436309544 creator A5057698564 @default.
• W2436309544 creator A5058102145 @default.
• W2436309544 creator A5061689322 @default.
• W2436309544 creator A5071068702 @default.
• W2436309544 creator A5072778023 @default.
• W2436309544 creator A5075724184 @default.
• W2436309544 creator A5088823841 @default.
• W2436309544 date "2016-12-01" @default.
• W2436309544 modified "2023-10-16" @default.
• W2436309544 title "Expression of RXFP1 Is Decreased in Idiopathic Pulmonary Fibrosis. Implications for Relaxin-based Therapies" @default.
• W2436309544 cites W1519148279 @default.
• W2436309544 cites W1537253598 @default.
• W2436309544 cites W1954728404 @default.
• W2436309544 cites W1990847332 @default.
• W2436309544 cites W1995158939 @default.
• W2436309544 cites W2010917040 @default.
• W2436309544 cites W2018338056 @default.
• W2436309544 cites W2019525662 @default.
• W2436309544 cites W2033955551 @default.
• W2436309544 cites W2059379939 @default.
• W2436309544 cites W2082370121 @default.
• W2436309544 cites W2083891358 @default.
• W2436309544 cites W2085522770 @default.
• W2436309544 cites W2090968333 @default.
• W2436309544 cites W2093799426 @default.
• W2436309544 cites W2095491346 @default.
• W2436309544 cites W2098530232 @default.
• W2436309544 cites W2099677690 @default.
• W2436309544 cites W2103793900 @default.
• W2436309544 cites W2105701716 @default.
• W2436309544 cites W2106406091 @default.
• W2436309544 cites W2115165513 @default.
• W2436309544 cites W2116163278 @default.
• W2436309544 cites W2117388663 @default.
• W2436309544 cites W2122808445 @default.
• W2436309544 cites W2126035033 @default.
• W2436309544 cites W2129416181 @default.
• W2436309544 cites W2138516319 @default.
• W2436309544 cites W2148913966 @default.
• W2436309544 cites W2159294289 @default.
• W2436309544 cites W2160489474 @default.
• W2436309544 cites W2160906692 @default.
• W2436309544 cites W3141986935 @default.
• W2436309544 cites W61403476 @default.
• W2436309544 doi "https://doi.org/10.1164/rccm.201509-1865oc" @default.
• W2436309544 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5148141" @default.
• W2436309544 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27310652" @default.
• W2436309544 hasPublicationYear "2016" @default.
• W2436309544 type Work @default.
• W2436309544 sameAs 2436309544 @default.
• W2436309544 citedByCount "44" @default.
• W2436309544 countsByYear W24363095442016 @default.
• W2436309544 countsByYear W24363095442017 @default.
• W2436309544 countsByYear W24363095442018 @default.
• W2436309544 countsByYear W24363095442019 @default.
• W2436309544 countsByYear W24363095442020 @default.
• W2436309544 countsByYear W24363095442021 @default.
• W2436309544 countsByYear W24363095442022 @default.
• W2436309544 countsByYear W24363095442023 @default.
• W2436309544 crossrefType "journal-article" @default.
• W2436309544 hasAuthorship W2436309544A5026015210 @default.
• W2436309544 hasAuthorship W2436309544A5027286465 @default.
• W2436309544 hasAuthorship W2436309544A5035257973 @default.
• W2436309544 hasAuthorship W2436309544A5040323862 @default.
• W2436309544 hasAuthorship W2436309544A5050693307 @default.
• W2436309544 hasAuthorship W2436309544A5051655241 @default.
• W2436309544 hasAuthorship W2436309544A5057698564 @default.
• W2436309544 hasAuthorship W2436309544A5058102145 @default.
• W2436309544 hasAuthorship W2436309544A5061689322 @default.
• W2436309544 hasAuthorship W2436309544A5071068702 @default.
• W2436309544 hasAuthorship W2436309544A5072778023 @default.
• W2436309544 hasAuthorship W2436309544A5075724184 @default.
• W2436309544 hasAuthorship W2436309544A5088823841 @default.
• W2436309544 hasBestOaLocation W24363095442 @default.
• W2436309544 hasConcept C126322002 @default.
• W2436309544 hasConcept C142724271 @default.
• W2436309544 hasConcept C150903083 @default.
• W2436309544 hasConcept C170493617 @default.
• W2436309544 hasConcept C207001950 @default.
• W2436309544 hasConcept C26291073 @default.
• W2436309544 hasConcept C2776232574 @default.
• W2436309544 hasConcept C2776694085 @default.
• W2436309544 hasConcept C2777121736 @default.
• W2436309544 hasConcept C2777714996 @default.
• W2436309544 hasConcept C2778341716 @default.
• W2436309544 hasConcept C2781244666 @default.
• W2436309544 hasConcept C71924100 @default.
• W2436309544 hasConcept C86803240 @default.
• W2436309544 hasConceptScore W2436309544C126322002 @default.
• W2436309544 hasConceptScore W2436309544C142724271 @default.

• next