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• W2436600145 abstract "Atypical fibroxanthoma (AFX) is a recently described soft tissue tumour by World Health Organization as a benign tumour of uncertain differentiation, occurring on sun exposed skin in elderly individual [1]. The bizarreness as well as marked atypia seen in the cells raises a first impression of malignant tumour, whereas it is rarely so. It has a male predominance (70%) with an average age of presentation of 71.9 years, ranging from 29–91 years [2].An 81-year-old male presented with hard nodular scalp swelling since 7 to 8 years with a rapid size increase since 3 months. On examination there was a nodulo-ulcerative lesion measuring 5cm x 3cm on scalp with bleeding edges. He did not have any other cutaneous lesion or lymphadenopathy. Excisional biopsy done outside was reported as sebaceous carcinoma. The patient was referred to our hospital for further management. On review of biopsy slides, the tumour cells were spindled, plump to epithelioid with marked pleomorphism, arranged in haphazard, vaguely fascicular or storiform patterns [Table/Fig-1a]. Tumour cells had hyperchromatic and multilobulated bizarre nuclei with scattered multinucleate tumour giant cells. Some cells of the lesion contained vacuolated and lipid-containing cytoplasm similar to xanthoma raising doubts of sebaceous carcinoma, as diagnosed outside [Table/Fig-1b]. On extensive IHC work up, the tumour cells were positive for Vimentin (Dako;V9) [Table/Fig-1c], CD68 (Leica;514H12), CD10 (Dako;56C6) [Table/Fig-1d] and negative for Cytokeratin (Biogenix;AE1+AE3) [Table/Fig-1e], EMA (Dako, E29), SMA (Dako;1A4), S 100 (Dako;IS504), Desmin (Dako;D33), Caldesmon (Dako; H-CD) and HMB 45 (Dako;HMB45) [Table/Fig-1f]. A final diagnosis of atypical fibroxanthoma was made.[Table/Fig-1]:Histopathological examination showing large bizarre cells with abundant foamy cytoplasm and atypical mitosis (HE b) 400x). Immunohistochemistry showing positivity for Vimentin (c), CD10 (d) and negativity for Cytokeratin (e), HMB45 ...Making a diagnosis of atypical fibroxanthoma is challenging and the diagnosis should be made by exclusion of other differential diagnoses after applying the stringent histological criteria and a broad panel of immunostains. Cutaneous carcinomas and melanoma must be ruled out by immunohistochemistry. Absent immunostaining for cytokeratins, S100 and HMB45 in AFX are helpful for excluding sebaceous carcinoma along with squamous cell carcinoma and malignant melanoma. Other differentials are malignant fibrohistiocytoma, atypical Fibrous Histiocytoma /dermatofibroma with monster Cells and pleomorphic fibroma [Table/Fig-2]. By definition, in AFX tumour cells lack expression of S100, cytokeratin, CD34, desmin and h-caldesmon. Previously our case was misdiagnosed as sebaceous carcinoma due to pleomorphism, abundant clear to foamy cytoplasm and bizarre pleomorphic nuclei. CD10 is a useful marker for AFX and is positive in 95%–100% cases of AFX [2]. A histiocytic marker CD 68 is positive in more than half of cases [3]. AFX shows a very good prognosis after surgical excision [4]. Reports of metastasis are very rare, and recurrence is uncommon [5]. Distinction from high grade sarcoma is crucial to prevent inappropriate aggressive therapy.[Table/Fig-2]:Differential diagnoses of atypical fibroxanthoma" @default.
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• W2436600145 date "2015-01-01" @default.
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• W2436600145 title "Atypical Fibroxanthoma of Scalp: A Paradoxical Benign Tumour" @default.
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• W2436600145 doi "https://doi.org/10.7860/jcdr/2015/16495.6937" @default.
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