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• W2436623623 abstract "Abstract Dom34-Hbs1 stimulates degradation of aberrant mRNAs lacking termination codons by dissociating ribosomes stalled at the 3′ ends and plays crucial roles in Nonstop Decay (NSD) and No-Go Decay (NGD). In the dom34 Δ mutant, nonstop mRNA is degraded by sequential endonucleolytic cleavages induced by a stalled ribosome at the 3′ end. Here, we report that ribosome-associated Asc1/RACK1 is required for the endonucleolytic cleavage of nonstop mRNA by stalled ribosome at the 3′ end of mRNA in dom34 Δ mutant cells. Asc1/RACK1 facilitates degradation of truncated GFP-Rz mRNA in the absence of Dom34 and exosome-dependent decay. Asc1/RACK1 is required for the sequential endonucleolytic cleavages by the stalled ribosome in the dom34 Δ mutant, depending on its ribosome-binding activity. The levels of peptidyl-tRNA derived from nonstop mRNA were elevated in dom34 Δ asc1 Δ mutant cells and overproduction of nonstop mRNA inhibited growth of mutant cells. E3 ubiquitin ligase Ltn1 degrades the arrest products from truncated GFP-Rz mRNA in dom34 Δ and dom34 Δ asc1 Δ mutant cells and Asc1/RACK1 represses the levels of substrates for Ltn1-dependent degradation. These indicate that ribosome-associated Asc1/RACK1 facilitates endonucleolytic cleavage of nonstop mRNA by stalled ribosomes and represses the levels of aberrant products even in the absence of Dom34. We propose that Asc1/RACK1 acts as a fail-safe in quality control for nonstop mRNA." @default.
• W2436623623 created "2016-06-24" @default.
• W2436623623 creator A5061026747 @default.
• W2436623623 creator A5061533640 @default.
• W2436623623 date "2016-06-17" @default.
• W2436623623 modified "2023-10-16" @default.
• W2436623623 title "Ribosome-associated Asc1/RACK1 is required for endonucleolytic cleavage induced by stalled ribosome at the 3′ end of nonstop mRNA" @default.
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• W2436623623 doi "https://doi.org/10.1038/srep28234" @default.
• W2436623623 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4911565" @default.
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