Matches in SemOpenAlex for { <https://semopenalex.org/work/W2436698380> ?p ?o ?g. }
- W2436698380 abstract "Abstract The aim of this study was to investigate the neural substrate underlying quality of life (QoL) and to demonstrate the microstructural abnormalities associated with impaired QoL in a large sample of patients with schizophrenia, using magnetisation transfer imaging. A total of 81 right-handed men with a diagnosis of schizophrenia and 25 age- and sex-similar healthy controls were included and underwent a 3T MRI with magnetization transfer ratio (MTR) to detect microstructural abnormalities. Compared with healthy controls, patients with schizophrenia had grey matter (GM) decreased MTR values in the temporal lobe (BA21, BA37 and BA38), the bilateral insula, the occipital lobe (BA17, BA18 and BA19) and the cerebellum. Patients with impaired QoL had lower GM MTR values relative to patients with preserved QoL in the bilateral temporal pole (BA38), the bilateral insula, the secondary visual cortex (BA18), the vermis and the cerebellum. Significant correlations between MTR values and QoL scores (p < 0.005) were observed in the GM of patients in the right temporal pole (BA38), the bilateral insula, the vermis and the right cerebellum. Our study shows that QoL impairment in patients with schizophrenia is related to the microstructural changes in an extensive network, suggesting that QoL is a bio-psychosocial marker." @default.
- W2436698380 created "2016-06-24" @default.
- W2436698380 creator A5020165832 @default.
- W2436698380 creator A5024632974 @default.
- W2436698380 creator A5034951444 @default.
- W2436698380 creator A5045007269 @default.
- W2436698380 creator A5047586802 @default.
- W2436698380 creator A5050790997 @default.
- W2436698380 creator A5072799008 @default.
- W2436698380 creator A5083509845 @default.
- W2436698380 creator A5091400465 @default.
- W2436698380 creator A5091742082 @default.
- W2436698380 date "2015-12-03" @default.
- W2436698380 modified "2023-09-28" @default.
- W2436698380 title "Neural substrate of quality of life in patients with schizophrenia: a magnetisation transfer imaging study" @default.
- W2436698380 cites W119903107 @default.
- W2436698380 cites W1935350642 @default.
- W2436698380 cites W1963804101 @default.
- W2436698380 cites W1967008995 @default.
- W2436698380 cites W1968596847 @default.
- W2436698380 cites W1970620350 @default.
- W2436698380 cites W1972601044 @default.
- W2436698380 cites W1987376751 @default.
- W2436698380 cites W1991037733 @default.
- W2436698380 cites W1991704415 @default.
- W2436698380 cites W1992023367 @default.
- W2436698380 cites W1994519701 @default.
- W2436698380 cites W1996155736 @default.
- W2436698380 cites W1999852284 @default.
- W2436698380 cites W2000399659 @default.
- W2436698380 cites W2003092280 @default.
- W2436698380 cites W2003366144 @default.
- W2436698380 cites W2006252007 @default.
- W2436698380 cites W2006527776 @default.
- W2436698380 cites W2008478545 @default.
- W2436698380 cites W2009416782 @default.
- W2436698380 cites W2012400612 @default.
- W2436698380 cites W2016578127 @default.
- W2436698380 cites W2020714449 @default.
- W2436698380 cites W2025489311 @default.
- W2436698380 cites W2031065729 @default.
- W2436698380 cites W2041042839 @default.
- W2436698380 cites W2055345898 @default.
- W2436698380 cites W2057522440 @default.
- W2436698380 cites W2057758167 @default.
- W2436698380 cites W2060093863 @default.
- W2436698380 cites W2066208486 @default.
- W2436698380 cites W2068787204 @default.
- W2436698380 cites W2070797083 @default.
- W2436698380 cites W2077567218 @default.
- W2436698380 cites W2079590167 @default.
- W2436698380 cites W2084697366 @default.
- W2436698380 cites W2086719660 @default.
- W2436698380 cites W2091194412 @default.
- W2436698380 cites W2099540319 @default.
- W2436698380 cites W2104492171 @default.
- W2436698380 cites W2105361499 @default.
- W2436698380 cites W2105527159 @default.
- W2436698380 cites W2110500286 @default.
- W2436698380 cites W2112103602 @default.
- W2436698380 cites W2114638865 @default.
- W2436698380 cites W2114870688 @default.
- W2436698380 cites W2119195417 @default.
- W2436698380 cites W2136666890 @default.
- W2436698380 cites W2140327288 @default.
- W2436698380 cites W2140606211 @default.
- W2436698380 cites W2141815570 @default.
- W2436698380 cites W2142658473 @default.
- W2436698380 cites W2151321983 @default.
- W2436698380 cites W2156014011 @default.
- W2436698380 cites W2157094615 @default.
- W2436698380 cites W2162959382 @default.
- W2436698380 cites W2163400471 @default.
- W2436698380 cites W2166793287 @default.
- W2436698380 cites W2167014559 @default.
- W2436698380 cites W2170644672 @default.
- W2436698380 cites W3004292749 @default.
- W2436698380 doi "https://doi.org/10.1038/srep17650" @default.
- W2436698380 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4668560" @default.
- W2436698380 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26632639" @default.
- W2436698380 hasPublicationYear "2015" @default.
- W2436698380 type Work @default.
- W2436698380 sameAs 2436698380 @default.
- W2436698380 citedByCount "15" @default.
- W2436698380 countsByYear W24366983802016 @default.
- W2436698380 countsByYear W24366983802017 @default.
- W2436698380 countsByYear W24366983802018 @default.
- W2436698380 countsByYear W24366983802019 @default.
- W2436698380 countsByYear W24366983802021 @default.
- W2436698380 countsByYear W24366983802022 @default.
- W2436698380 countsByYear W24366983802023 @default.
- W2436698380 crossrefType "journal-article" @default.
- W2436698380 hasAuthorship W2436698380A5020165832 @default.
- W2436698380 hasAuthorship W2436698380A5024632974 @default.
- W2436698380 hasAuthorship W2436698380A5034951444 @default.
- W2436698380 hasAuthorship W2436698380A5045007269 @default.
- W2436698380 hasAuthorship W2436698380A5047586802 @default.
- W2436698380 hasAuthorship W2436698380A5050790997 @default.
- W2436698380 hasAuthorship W2436698380A5072799008 @default.
- W2436698380 hasAuthorship W2436698380A5083509845 @default.