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- W2436700469 abstract "OBJECTIVE To observe the cytotoxicity of bovine aortic endothelial cells (BAEC) by different kinds of arsenicals. METHODS Cultured BAEC was exposed to arsenite (iAsIII , 0 - 50 micromol/L), arsenate (iAsV ,0 - 10mmol/L) or monomethylarsonous acid (MMAH III, 0 - 2micromol/L) for 24h, respectively. MTT assay and ICP-MS method were used to evaluate the cell viability and the total arsenic concentration (tAs) of BAEC, respectively. RESULTS iAsm , iAsV and MMAIII could all decrease the cell viability in a dose-dependent manner (P iAsIII > iAsV . The take-up rate of MMA' by BAEC was significantly higher than iAsR exposure (P < 0.01). CONCLUSION MMAIII , one of the active intermediate in inorganic arsenic methylation, is highly toxic in BAEC. Methylation of arsenic could be more like a bioactivation process rather than a detoxification process." @default.
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- W2436700469 date "2006-11-01" @default.
- W2436700469 modified "2023-09-28" @default.
- W2436700469 title "Cytotoxicity study of vascular endothelial cells by different kinds of arsenicals" @default.
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