Matches in SemOpenAlex for { <https://semopenalex.org/work/W2436700741> ?p ?o ?g. }
- W2436700741 endingPage "304" @default.
- W2436700741 startingPage "297" @default.
- W2436700741 abstract "Hepatocellular carcinoma (HCC) is third in cancer-related causes of death worldwide and its treatment is a significant unmet medical need. Sunitinib is a selective tyrosine kinase inhibitor of the angiogenic biomarker: soluble vascular endothelial growth factor receptor-2 (sVEGFR2 ). Sunitinib failed its primary overall survival endpoint in patients with advanced HCC in a phase III trial compared to sorafenib. In the present study, pharmacokinetic-pharmacodynamic modeling was used to link drug-exposure to tumor-growth-inhibition (TGI) and time-to-tumor progression (TTP) through sVEGFR2 dynamics. The results suggest that 1) active drug concentration (i.e., sunitinib and its metabolite) inhibits the release of sVEGFR2 and that such inhibition is associated with TGI, and 2) daily sVEGFR2 exposure is likely a reliable predictor for the TTP in HCC patients. Moreover, the model quantitatively links the dynamics of an angiogenesis biomarker to TTP and accurately predicts observed literature-reported results of placebo treatment." @default.
- W2436700741 created "2016-06-24" @default.
- W2436700741 creator A5004009056 @default.
- W2436700741 creator A5008304955 @default.
- W2436700741 creator A5037345000 @default.
- W2436700741 creator A5055725897 @default.
- W2436700741 creator A5056838045 @default.
- W2436700741 creator A5060308792 @default.
- W2436700741 creator A5062284417 @default.
- W2436700741 creator A5065234769 @default.
- W2436700741 date "2016-06-01" @default.
- W2436700741 modified "2023-10-05" @default.
- W2436700741 title "Bridging Sunitinib Exposure to Time‐to‐Tumor Progression in Hepatocellular Carcinoma Patients With Mathematical Modeling of an Angiogenic Biomarker" @default.
- W2436700741 cites W129437821 @default.
- W2436700741 cites W1968516337 @default.
- W2436700741 cites W1971837077 @default.
- W2436700741 cites W1976689062 @default.
- W2436700741 cites W1978139448 @default.
- W2436700741 cites W1989401206 @default.
- W2436700741 cites W1995168398 @default.
- W2436700741 cites W2006113962 @default.
- W2436700741 cites W2019607817 @default.
- W2436700741 cites W2019832083 @default.
- W2436700741 cites W2020830322 @default.
- W2436700741 cites W2028160054 @default.
- W2436700741 cites W2031614751 @default.
- W2436700741 cites W2040070170 @default.
- W2436700741 cites W2042415282 @default.
- W2436700741 cites W2044254728 @default.
- W2436700741 cites W2044864412 @default.
- W2436700741 cites W2047508936 @default.
- W2436700741 cites W2070134026 @default.
- W2436700741 cites W2073826833 @default.
- W2436700741 cites W2077572075 @default.
- W2436700741 cites W2092773777 @default.
- W2436700741 cites W2109746877 @default.
- W2436700741 cites W2113788015 @default.
- W2436700741 cites W2115553491 @default.
- W2436700741 cites W2119671639 @default.
- W2436700741 cites W2123334268 @default.
- W2436700741 cites W2125122572 @default.
- W2436700741 cites W2133423870 @default.
- W2436700741 cites W2134473118 @default.
- W2436700741 cites W2137052325 @default.
- W2436700741 cites W2138610774 @default.
- W2436700741 cites W2149032069 @default.
- W2436700741 cites W2152099731 @default.
- W2436700741 cites W2153935627 @default.
- W2436700741 cites W2163243560 @default.
- W2436700741 cites W2163738584 @default.
- W2436700741 cites W2166973314 @default.
- W2436700741 cites W2171608750 @default.
- W2436700741 cites W2249480904 @default.
- W2436700741 cites W2321119966 @default.
- W2436700741 cites W4211105405 @default.
- W2436700741 cites W4244491773 @default.
- W2436700741 cites W4245403358 @default.
- W2436700741 doi "https://doi.org/10.1002/psp4.12084" @default.
- W2436700741 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5131886" @default.
- W2436700741 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27300260" @default.
- W2436700741 hasPublicationYear "2016" @default.
- W2436700741 type Work @default.
- W2436700741 sameAs 2436700741 @default.
- W2436700741 citedByCount "8" @default.
- W2436700741 countsByYear W24367007412017 @default.
- W2436700741 countsByYear W24367007412018 @default.
- W2436700741 countsByYear W24367007412020 @default.
- W2436700741 countsByYear W24367007412021 @default.
- W2436700741 countsByYear W24367007412023 @default.
- W2436700741 crossrefType "journal-article" @default.
- W2436700741 hasAuthorship W2436700741A5004009056 @default.
- W2436700741 hasAuthorship W2436700741A5008304955 @default.
- W2436700741 hasAuthorship W2436700741A5037345000 @default.
- W2436700741 hasAuthorship W2436700741A5055725897 @default.
- W2436700741 hasAuthorship W2436700741A5056838045 @default.
- W2436700741 hasAuthorship W2436700741A5060308792 @default.
- W2436700741 hasAuthorship W2436700741A5062284417 @default.
- W2436700741 hasAuthorship W2436700741A5065234769 @default.
- W2436700741 hasBestOaLocation W24367007411 @default.
- W2436700741 hasConcept C111113717 @default.
- W2436700741 hasConcept C112705442 @default.
- W2436700741 hasConcept C121608353 @default.
- W2436700741 hasConcept C126322002 @default.
- W2436700741 hasConcept C143998085 @default.
- W2436700741 hasConcept C167734588 @default.
- W2436700741 hasConcept C2777025900 @default.
- W2436700741 hasConcept C2778019345 @default.
- W2436700741 hasConcept C2778439243 @default.
- W2436700741 hasConcept C2778695046 @default.
- W2436700741 hasConcept C2779490328 @default.
- W2436700741 hasConcept C2780394083 @default.
- W2436700741 hasConcept C2781197716 @default.
- W2436700741 hasConcept C55493867 @default.
- W2436700741 hasConcept C71924100 @default.
- W2436700741 hasConcept C86803240 @default.
- W2436700741 hasConcept C98274493 @default.
- W2436700741 hasConceptScore W2436700741C111113717 @default.
- W2436700741 hasConceptScore W2436700741C112705442 @default.