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• W2436718607 abstract "4455 Proteomic biomarkers that either distinguish women who are at risk of developing cervical cancer or detect its precursor lesions will have significant impact on early detection and reduced mortality. Although preventable and curable if detected early, cervical cancer is still the second most common cancer in women worldwide and the leading cause of cancer-related deaths in women in developing countries where cytology screening programs have shown to be ineffective. The current use of biopsy tissue for cervical cancer biomarkers development represents a limiting factor because it is invasive and does not allow having access to a large number of specimens - not only from patients but also from healthy controls - which is critical for biomarkers discovery and validation. To address this issue, protein was isolated from a total of 24 cervical scrapings collected from women attending the OB/GYN clinics operated under the University of Texas Medical Branch at Galveston. The pool of samples included women presenting with normal cytology as well as patients with a wide spectrum of clinical diagnosis. For the purpose of the present study only patients with high-grade squamous intraepithelial lesion (HSIL) confirmed by colposcopy and/or biopsy (cases; N=4); and women with negative Pap test and no prior history of abnormal cytology (controls; N=3) were selected for two dimensional gel electrophoresis (2DGE) analysis. All three control gels were normalized to create an average control gel which was compared individually to all four cases. A total of 79 spots at least 2 folds differentially expressed were identified and selected for spot picking, trypsin digestion and peptide mass fingerprinting by matrix-assisted laser desorption ionization - time-of-flight / time-of-flight - mass spectrometry (MALDI-TOF/TOF-MS). Thirty-four (34) proteins were identified with expectation values greater than 10 −3 and were expressed either only in cases, only in controls, higher in cases or higher in controls. Among the derived proteins are members of the ovalbumin serine proteinase inhibitors, calcium-binding proteins, keratins, human actin-binding proteins, cysteine proteinase inhibitors and proteins involved in cellular glycolysis, cytokinesis, and metastasis. In addition to some previously reported protein biomarkers in biopsy specimens from cervical tumors, a subset of new biomarkers was identified in this study. Our results demonstrate the feasibility of proteomic analysis of exfoliated cervical epithelial cells as a promising tool for the development of biomarkers for cervical cancer." @default.
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• W2436718607 date "2006-04-15" @default.
• W2436718607 modified "2023-09-24" @default.
• W2436718607 title "Biomarkers for cervical cancer generated by proteomic analysis of exfoliated cervical epithelial cells" @default.
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