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- W2437090812 abstract "To discuss the impact of comorbidities on the outcomes of patients with MDS.The clinical characteristics of 676 MDS patients with detailed comorbidities evaluations was analyzed retrospectively.There were 395/676 cases (58.4%) with comorbidities (group 1), 281/676 cases (41.6%) without (group 2). Significant differences were seen in the distribution of age (≥ 60 y), bone marrow blasts, abnormal karyotype, WHO 2008 subtypes and IPSS-R risk cohorts (P<0.05) between the two groups. While gender, HGB concentrations, WBC levels, platelet levels and serum ferritin were not significantly different (P>0.05). Independent prognostic significance of comorbidities was seen in both uni-variate and multi-variate analyses (P<0.001). According to MDS-specific comorbidity index (MDS-CI), the median survival were 32(1-153) months, 19(2-85) months and 13(1-37) months in the low-risk, intermediate-risk and high-risk cohorts respectively, while 96(1-166) months in cohorts without any comorbidities, of which significant differences were seen (P<0.001). The MDS-CI allowed further stratification in the IPSS-R low-risk, intermediate-risk and high-risk cohorts (P<0.001).Comorbidities provides prognostic stratification independently of IPSS-R for MDS patients." @default.
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- W2437090812 date "2015-03-01" @default.
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- W2437090812 title "[Prognostic evaluation of comorbidities in patients with myelodysplastic syndrome]." @default.
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- W2437090812 doi "https://doi.org/10.3760/cma.j.issn.0253-2727.2015.03.005" @default.
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