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- W2437112943 abstract "OBJECTIVE: To evaluate the effect of dalfampridine extended release (D-ER) 10 mg tablets twice daily on different domains of walking in patients with Parkinson’s disease (PD).BACKGROUND: Gait related disability is the most troublesome feature of PD and effective treatment options are lacking.DESIGN/METHODS: 22 patients with PD and gait dysfunction were randomized to receive D-ER 10 mg twice daily or placebo for 4 weeks in a crossover design with a 2 week washout period. The primary outcomes were change in the stride length and velocity, measured by movement analysis system. Secondary outcome measures included: United Parkinson Disease Rating Scale (UPDRS part III) and Freezing of Gait Questionnaire (FOGQ). Safety and Tolerability were assessed.RESULTS: 18 PD patients completed the study; mean age, 67.5±8.7. Baseline scores for motor UPDRS and FOGQ were 36.6±14.1 and 14.1±5.3, respectively. At 4 weeks, velocity was not significantly different between D-ER (0.89 m/s ±0.33) and placebo (0.93 m/s ±0.27) conditions. The stride length was also similar between conditions: 0.96m ±0.38 for D-ER versus 1.06m ±0.33 for placebo. A trend for improvement in the motor UPDRS (1.8, p=0.34) and FOGQ (0.9 p=0.19) after 4 weeks of D-ER was identified (large effect size, p-nonsignificant). Responder analysis showed significant improvements with D-ER in 10 patients in UPDRS (-6.6 ±2.7, p=0.02), PIGD score (-3.2±1.02, p=0.004) and FOGQ (-2.1±0.8, p=0.01). D-ER was generally well tolerated with the most frequent side effects being dizziness, nausea and balance problems.CONCLUSIONS: D-ER is well tolerated in PD patients. The beneficial effects seen in UPDRS, PIGD score and self-reported FOGQ suggest that D-ER may potentially have favorable effects in certain aspects of walking in patients with PD. Larger studies are necessary to establish the effects of D-ER in patients with PD and gait dysfunction. Study supported by: AAN CRTF and ACORDA. Disclosure: Dr. Luca has nothing to disclose. Dr. Nadayil has nothing to disclose. Dr. Dong has nothing to disclose. Dr. Field-Fote has nothing to disclose. Dr. Singer has received personal compensation for activities with Lundbeck Research USA, Inc., and Allergan, Inc. Dr. Singer has received research support from Allergan, Inc., Teva Neuroscience, and Ipsen." @default.
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- W2437112943 date "2015-04-06" @default.
- W2437112943 modified "2023-09-24" @default.
- W2437112943 title "Dalfampridine extended release in patients with Parkinson’s disease related gait dysfunction: A randomized double blind trial. (P6.049)" @default.
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