FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2437644823> ?p ?o ?g. }

• W2437644823 endingPage "8" @default.
• W2437644823 startingPage "280" @default.
• W2437644823 abstract "We investigated the effect of oral anticoagulation on thrombogenesis induced by the subendothelium of rabbit aorta. Eighteen healthy volunteers underwent a 2-week treatment with the oral coumarin preparation phenprocoumon to a target international normalized ratio (INR) of 5. By using an ex-vivo perfusion chamber system, the interaction between flowing blood and exposed subendothelium was measured at low (50 sec-1) and high (650 sec-1) wall shear rates. The low shear rate simulated blood flow in venous vessels and the high shear rate simulated blood flow in arterial vessels. Deposition of fibrin, platelets, and platelet thrombi on subendothelium was quantified by morphometric and immunologic techniques. Fibrin deposition prevailed at the low shear rate (183 +/- 57 ng/mm2 vs 46 +/- 16 ng/mm2, low vs high shear rate; mean +/- SEM; p less than 0.01). In contrast, the interaction of platelets with subendothelium was more intense at high shear rates when compared with low shear rates, as indicated by higher platelet adhesion (44% +/- 2% vs 9% +/- 1% coverage of subendothelium with platelets, p less than 0.001) and platelet thrombus volumes (3.6 +/- 0.4 microns 3/microns 2 vs 1.3 +/- 0.3 microns 3/microns 2, p less than 0.001). Fibrin deposition on subendothelium was substantially reduced even at a low intensity of anticoagulation (reduction by 60% at INR 2.1 and by 75% at INR 3.7) and was abolished after high coumarin doses (INR 5.2). In contrast, a significant inhibition of platelet thrombus formation could be achieved only by high doses of phenprocoumon (INR 5.2). Our data indicate that relatively low doses of oral anticoagulants (INR between 2 and 3.5) substantially inhibit the fibrin formation on subendothelium prevailing at venous shear conditions, whereas a high intensity of anticoagulation (INR 4 to 5) is necessary to inhibit the formation of platelet-rich thrombi prevailing at arterial shear conditions." @default.
• W2437644823 created "2016-06-24" @default.
• W2437644823 creator A5007253601 @default.
• W2437644823 creator A5028252485 @default.
• W2437644823 creator A5036665264 @default.
• W2437644823 creator A5052345226 @default.
• W2437644823 creator A5076483085 @default.
• W2437644823 date "1991-09-01" @default.
• W2437644823 modified "2023-09-23" @default.
• W2437644823 title "Effects of the oral anticoagulant phenprocoumon on blood coagulation and thrombogenesis induced by rabbit aorta subendothelium exposed to flowing human blood: role of dose and shear rate." @default.
• W2437644823 cites W122338835 @default.
• W2437644823 cites W1234774043 @default.
• W2437644823 cites W1978039741 @default.
• W2437644823 cites W1979698812 @default.
• W2437644823 cites W1990477262 @default.
• W2437644823 cites W199258423 @default.
• W2437644823 cites W2000143312 @default.
• W2437644823 cites W2002482714 @default.
• W2437644823 cites W2002532777 @default.
• W2437644823 cites W2004863362 @default.
• W2437644823 cites W2008765246 @default.
• W2437644823 cites W2011456513 @default.
• W2437644823 cites W2019588710 @default.
• W2437644823 cites W2032075252 @default.
• W2437644823 cites W2058003319 @default.
• W2437644823 cites W2061607137 @default.
• W2437644823 cites W2072581339 @default.
• W2437644823 cites W2076308915 @default.
• W2437644823 cites W2097190188 @default.
• W2437644823 cites W2106352950 @default.
• W2437644823 cites W2113166567 @default.
• W2437644823 cites W2129345995 @default.
• W2437644823 cites W2141735215 @default.
• W2437644823 cites W2150608680 @default.
• W2437644823 cites W2153530728 @default.
• W2437644823 cites W2155219561 @default.
• W2437644823 cites W2163335326 @default.
• W2437644823 cites W2218416533 @default.
• W2437644823 cites W2240894292 @default.
• W2437644823 cites W2345733312 @default.
• W2437644823 cites W2403343283 @default.
• W2437644823 cites W2414160344 @default.
• W2437644823 cites W2421579454 @default.
• W2437644823 cites W2475319454 @default.
• W2437644823 cites W2884734320 @default.
• W2437644823 cites W999465543 @default.
• W2437644823 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1919300" @default.
• W2437644823 hasPublicationYear "1991" @default.
• W2437644823 type Work @default.
• W2437644823 sameAs 2437644823 @default.
• W2437644823 citedByCount "3" @default.
• W2437644823 crossrefType "journal-article" @default.
• W2437644823 hasAuthorship W2437644823A5007253601 @default.
• W2437644823 hasAuthorship W2437644823A5028252485 @default.
• W2437644823 hasAuthorship W2437644823A5036665264 @default.
• W2437644823 hasAuthorship W2437644823A5052345226 @default.
• W2437644823 hasAuthorship W2437644823A5076483085 @default.
• W2437644823 hasConcept C126322002 @default.
• W2437644823 hasConcept C127172972 @default.
• W2437644823 hasConcept C146957229 @default.
• W2437644823 hasConcept C158846371 @default.
• W2437644823 hasConcept C159985019 @default.
• W2437644823 hasConcept C164705383 @default.
• W2437644823 hasConcept C165682214 @default.
• W2437644823 hasConcept C185592680 @default.
• W2437644823 hasConcept C192562407 @default.
• W2437644823 hasConcept C203014093 @default.
• W2437644823 hasConcept C2775876007 @default.
• W2437644823 hasConcept C2776301958 @default.
• W2437644823 hasConcept C2777871224 @default.
• W2437644823 hasConcept C2778382381 @default.
• W2437644823 hasConcept C2779161974 @default.
• W2437644823 hasConcept C2781362458 @default.
• W2437644823 hasConcept C45393284 @default.
• W2437644823 hasConcept C500558357 @default.
• W2437644823 hasConcept C54173615 @default.
• W2437644823 hasConcept C71924100 @default.
• W2437644823 hasConcept C89560881 @default.
• W2437644823 hasConceptScore W2437644823C126322002 @default.
• W2437644823 hasConceptScore W2437644823C127172972 @default.
• W2437644823 hasConceptScore W2437644823C146957229 @default.
• W2437644823 hasConceptScore W2437644823C158846371 @default.
• W2437644823 hasConceptScore W2437644823C159985019 @default.
• W2437644823 hasConceptScore W2437644823C164705383 @default.
• W2437644823 hasConceptScore W2437644823C165682214 @default.
• W2437644823 hasConceptScore W2437644823C185592680 @default.
• W2437644823 hasConceptScore W2437644823C192562407 @default.
• W2437644823 hasConceptScore W2437644823C203014093 @default.
• W2437644823 hasConceptScore W2437644823C2775876007 @default.
• W2437644823 hasConceptScore W2437644823C2776301958 @default.
• W2437644823 hasConceptScore W2437644823C2777871224 @default.
• W2437644823 hasConceptScore W2437644823C2778382381 @default.
• W2437644823 hasConceptScore W2437644823C2779161974 @default.
• W2437644823 hasConceptScore W2437644823C2781362458 @default.
• W2437644823 hasConceptScore W2437644823C45393284 @default.
• W2437644823 hasConceptScore W2437644823C500558357 @default.
• W2437644823 hasConceptScore W2437644823C54173615 @default.
• W2437644823 hasConceptScore W2437644823C71924100 @default.

• next