Matches in SemOpenAlex for { <https://semopenalex.org/work/W2437730963> ?p ?o ?g. }
Showing items 1 to 66 of
66
with 100 items per page.
- W2437730963 endingPage "17" @default.
- W2437730963 startingPage "3" @default.
- W2437730963 abstract "Passive cellular absorption of first glucose (Glu) and then fatty acids (FA) as substrate for energy generation formed during phylogeny. Glucose transporters ensure Glu absorption; the cells absorb FA as polar unetherified FA from the associates with albumin and oxidize them at once. Later there was an active cell absorption of saturated and unsaturated (with one-three double bonds) FAs as nonpolar triglycerides as part of very low-density lipoproteins via apoB-100 receptor-mediated endocytosis. When the biological function of locomotion was established, there was an insulin (Ins) system; the latter initiated apoE vector synthesis and targeted FA transfer mainly to skeletal myocytes and formed apoE/B-100 endocytosis. The major role of Ins is energy provision for the biological function of locomotion. Ins blocks the lipolysis and oxidation of FA in the myocytes until the cytosol contains sufficient Glu, and activates its absorption from the intercellular medium. FA lipolysis and oxidation begin only in glycopenia. Activation of myocytic FA oxidation with normal Glu levels and blocked lipolysis underlies Ins resistance. This occurs with: a) activated biological function of adaptation, a biological stress reaction, and the elevated intercellular levels of unetherified FAs that are passively absorbed and oxidized by cells; b) impaired biological function in exotrophy--high dietary palmitinic FA levels, a biological reaction of FA transfer to the cells, and blockade of apoE/B-100 endocytosis; c) impaired biological function of endoecology, purity of the intercellular medium, biological function of inflammation, and synthesis of lipid transfer C-reactive protein that as a vector redirects a flux of FA from myocytes to interstitial cells that realize the systemic inflammatory response syndrome. Since the formation of biological functions of adaptation, exotrophy, and endoecology occurred earlier than that of biological function of locomotion, Ins resistance is the enhanced passive cell absorption of FA, as this took place before the function of locomotion was formed. According to our described principle of biological subordination, phylogenetically later Ins cannot regulate the processes formed in earlier steps of phylogeny." @default.
- W2437730963 created "2016-06-24" @default.
- W2437730963 creator A5078243433 @default.
- W2437730963 date "2010-06-01" @default.
- W2437730963 modified "2023-09-28" @default.
- W2437730963 title "[Phylogeny, development of processes of cellular fatty acid transfer and absorption, biological locomotion function, and insulin function. Pathogenesis of insulin resistance syndrome]." @default.
- W2437730963 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20737705" @default.
- W2437730963 hasPublicationYear "2010" @default.
- W2437730963 type Work @default.
- W2437730963 sameAs 2437730963 @default.
- W2437730963 citedByCount "0" @default.
- W2437730963 crossrefType "journal-article" @default.
- W2437730963 hasAuthorship W2437730963A5078243433 @default.
- W2437730963 hasConcept C134018914 @default.
- W2437730963 hasConcept C140985366 @default.
- W2437730963 hasConcept C170493617 @default.
- W2437730963 hasConcept C171089720 @default.
- W2437730963 hasConcept C185592680 @default.
- W2437730963 hasConcept C25095133 @default.
- W2437730963 hasConcept C2777391703 @default.
- W2437730963 hasConcept C2779306644 @default.
- W2437730963 hasConcept C28005876 @default.
- W2437730963 hasConcept C55493867 @default.
- W2437730963 hasConcept C86803240 @default.
- W2437730963 hasConceptScore W2437730963C134018914 @default.
- W2437730963 hasConceptScore W2437730963C140985366 @default.
- W2437730963 hasConceptScore W2437730963C170493617 @default.
- W2437730963 hasConceptScore W2437730963C171089720 @default.
- W2437730963 hasConceptScore W2437730963C185592680 @default.
- W2437730963 hasConceptScore W2437730963C25095133 @default.
- W2437730963 hasConceptScore W2437730963C2777391703 @default.
- W2437730963 hasConceptScore W2437730963C2779306644 @default.
- W2437730963 hasConceptScore W2437730963C28005876 @default.
- W2437730963 hasConceptScore W2437730963C55493867 @default.
- W2437730963 hasConceptScore W2437730963C86803240 @default.
- W2437730963 hasIssue "6" @default.
- W2437730963 hasLocation W24377309631 @default.
- W2437730963 hasLocation W24377309632 @default.
- W2437730963 hasOpenAccess W2437730963 @default.
- W2437730963 hasPrimaryLocation W24377309631 @default.
- W2437730963 hasRelatedWork W1430845406 @default.
- W2437730963 hasRelatedWork W1508050262 @default.
- W2437730963 hasRelatedWork W2014671368 @default.
- W2437730963 hasRelatedWork W2030643479 @default.
- W2437730963 hasRelatedWork W2045569065 @default.
- W2437730963 hasRelatedWork W2071962989 @default.
- W2437730963 hasRelatedWork W2086082646 @default.
- W2437730963 hasRelatedWork W2087613739 @default.
- W2437730963 hasRelatedWork W2105923675 @default.
- W2437730963 hasRelatedWork W2134922062 @default.
- W2437730963 hasRelatedWork W2160533556 @default.
- W2437730963 hasRelatedWork W2379759392 @default.
- W2437730963 hasRelatedWork W2407123832 @default.
- W2437730963 hasRelatedWork W2443525606 @default.
- W2437730963 hasRelatedWork W2443995384 @default.
- W2437730963 hasRelatedWork W2472542109 @default.
- W2437730963 hasRelatedWork W2560221106 @default.
- W2437730963 hasRelatedWork W3166024029 @default.
- W2437730963 hasRelatedWork W40748525 @default.
- W2437730963 hasRelatedWork W3007167672 @default.
- W2437730963 isParatext "false" @default.
- W2437730963 isRetracted "false" @default.
- W2437730963 magId "2437730963" @default.
- W2437730963 workType "article" @default.