FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2437825530> ?p ?o ?g. }

• W2437825530 endingPage "44329" @default.
• W2437825530 startingPage "44322" @default.
• W2437825530 abstract "Cancer of unknown primary (CUP) is defined as metastatic solid malignancy where no primary tumor is detected despite appropriate staging. About 90% of CUP represent adenocarcinoma or undifferentiated carcinoma. Since therapy regimens are only modestly effective, identification of the molecular landscape of these neoplasms might be a promising approach to direct CUP therapy and aid in tumor classification. We screened a cohort of 128 patients with adenocarcinoma or undifferentiated carcinoma meeting the definition of CUP. Massive parallel multigene sequencing of 50 genes, which had been selected due to their relevance as oncogenic drivers or druggable molecular targets could ultimately be performed on samples from 55 patients for whom complete clinical datasets were also available. Overall, 60 tumor-specific mutations and 29 amplifications/deletions, as revealed by coverage analysis, were detected in 46 cases (84%). The most frequently mutated genes were TP53 (30 cases, 55%), KRAS (9 cases, 16%), CDKN2A (5 cases, 9%), and SMAD4 (5 cases, 9%). The most frequently deleted gene was CDKN2A (8 cases, 15%). KRAS and CDKN2A mutations significantly correlated with poor progression-free survival (PFS) and, in case of KRAS, overall survival (OS). WIldtype TP53 and female sex defined a relatively favorable category, with favorable PFS and OS. 8 cases (15%) harbored mutations that may be targetable by currently approved drugs. Taken together, Mutations of relevant driver genes are present in the vast majority of CUP tumors. Some of them impact on prognosis and a subset is putatively druggable." @default.
• W2437825530 created "2016-06-24" @default.
• W2437825530 creator A5003729966 @default.
• W2437825530 creator A5018744564 @default.
• W2437825530 creator A5019710731 @default.
• W2437825530 creator A5026607584 @default.
• W2437825530 creator A5051943219 @default.
• W2437825530 creator A5054109395 @default.
• W2437825530 creator A5062227589 @default.
• W2437825530 creator A5072724582 @default.
• W2437825530 creator A5078217749 @default.
• W2437825530 creator A5078452627 @default.
• W2437825530 creator A5087348033 @default.
• W2437825530 date "2016-06-14" @default.
• W2437825530 modified "2023-10-14" @default.
• W2437825530 title "Molecular driver alterations and their clinical relevance in cancer of unknown primary site" @default.
• W2437825530 cites W122083802 @default.
• W2437825530 cites W152480201 @default.
• W2437825530 cites W1803857749 @default.
• W2437825530 cites W1970015742 @default.
• W2437825530 cites W1979166355 @default.
• W2437825530 cites W1980810506 @default.
• W2437825530 cites W1986076152 @default.
• W2437825530 cites W1996689640 @default.
• W2437825530 cites W2031479345 @default.
• W2437825530 cites W2049137769 @default.
• W2437825530 cites W2051361303 @default.
• W2437825530 cites W2060688862 @default.
• W2437825530 cites W2065891752 @default.
• W2437825530 cites W2067795112 @default.
• W2437825530 cites W2078276694 @default.
• W2437825530 cites W2081990599 @default.
• W2437825530 cites W2085621354 @default.
• W2437825530 cites W2091493266 @default.
• W2437825530 cites W2093065590 @default.
• W2437825530 cites W2094424714 @default.
• W2437825530 cites W2098092368 @default.
• W2437825530 cites W2105616976 @default.
• W2437825530 cites W2110309421 @default.
• W2437825530 cites W2112180493 @default.
• W2437825530 cites W2113895281 @default.
• W2437825530 cites W2114473143 @default.
• W2437825530 cites W2138155367 @default.
• W2437825530 cites W2157824687 @default.
• W2437825530 cites W2161179758 @default.
• W2437825530 cites W2161386069 @default.
• W2437825530 cites W2161821474 @default.
• W2437825530 cites W2201713764 @default.
• W2437825530 cites W2204695746 @default.
• W2437825530 cites W2261220914 @default.
• W2437825530 cites W2331280832 @default.
• W2437825530 cites W2406106220 @default.
• W2437825530 cites W4231346141 @default.
• W2437825530 doi "https://doi.org/10.18632/oncotarget.10035" @default.
• W2437825530 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5190099" @default.
• W2437825530 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27322425" @default.
• W2437825530 hasPublicationYear "2016" @default.
• W2437825530 type Work @default.
• W2437825530 sameAs 2437825530 @default.
• W2437825530 citedByCount "44" @default.
• W2437825530 countsByYear W24378255302017 @default.
• W2437825530 countsByYear W24378255302018 @default.
• W2437825530 countsByYear W24378255302019 @default.
• W2437825530 countsByYear W24378255302020 @default.
• W2437825530 countsByYear W24378255302021 @default.
• W2437825530 countsByYear W24378255302022 @default.
• W2437825530 countsByYear W24378255302023 @default.
• W2437825530 crossrefType "journal-article" @default.
• W2437825530 hasAuthorship W2437825530A5003729966 @default.
• W2437825530 hasAuthorship W2437825530A5018744564 @default.
• W2437825530 hasAuthorship W2437825530A5019710731 @default.
• W2437825530 hasAuthorship W2437825530A5026607584 @default.
• W2437825530 hasAuthorship W2437825530A5051943219 @default.
• W2437825530 hasAuthorship W2437825530A5054109395 @default.
• W2437825530 hasAuthorship W2437825530A5062227589 @default.
• W2437825530 hasAuthorship W2437825530A5072724582 @default.
• W2437825530 hasAuthorship W2437825530A5078217749 @default.
• W2437825530 hasAuthorship W2437825530A5078452627 @default.
• W2437825530 hasAuthorship W2437825530A5087348033 @default.
• W2437825530 hasBestOaLocation W24378255301 @default.
• W2437825530 hasConcept C104317684 @default.
• W2437825530 hasConcept C10679952 @default.
• W2437825530 hasConcept C121608353 @default.
• W2437825530 hasConcept C126322002 @default.
• W2437825530 hasConcept C143998085 @default.
• W2437825530 hasConcept C146357865 @default.
• W2437825530 hasConcept C151730666 @default.
• W2437825530 hasConcept C2779013556 @default.
• W2437825530 hasConcept C2779399171 @default.
• W2437825530 hasConcept C2780265364 @default.
• W2437825530 hasConcept C2780283643 @default.
• W2437825530 hasConcept C2781182431 @default.
• W2437825530 hasConcept C2781187634 @default.
• W2437825530 hasConcept C502942594 @default.
• W2437825530 hasConcept C526805850 @default.
• W2437825530 hasConcept C54355233 @default.
• W2437825530 hasConcept C60644358 @default.
• W2437825530 hasConcept C63363279 @default.

• next