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• W2438053132 abstract "Malaria is a global disease and kills over 30 % to 40 % of children in endemic areas or developing countries, including Indonesia. Healing rates of malaria is affected by micronutrient body consumption such as vitamin A. Vitamin A plays an important role in enhancing the immune system. Vitamin A deficiency may weaken the body’s resistance to infectious diseases. This study aims to examine potent dose of vitamin A that induces an immune response as an immunomodulator using experimental mice infected with Plasmodium berghei through cellular immunity parameters analysis. This research was an experimental laboratory, designed as Post Test-Only Control Group Design. Experimental male Swiss Strain mice, which were eight weeks old, healthy and weighed 28.80 g to 31.20 g, were treated with standard feeding and drinking through ad libitum. A total of 24 mice which had been adapted for a week were randomly divided into four groups: K (control); P1 (solvent of vitamin A); P2 (treated with vitamin A and doses of 3 000 IU) and P3 (treated with vitamin A and doses of 6 000 IU) for examination of the cellular immune response. Oral administration of vitamin A was given one week before and 1 h after infection. All mice were infected with 107 cell · ml-1 Plasmodium berghei intraperitoneally on 15 d. On the 25 d, all mice were killed and examined for the level of IL-12, IFN-γ levels and macrophage phagocytosis index. Test results were analyzed by ANOVA with significance limit < 0.05. Result showed that vitamin A improved cellular immune response characterized by increasing levels of IL-12, IFN-γ and macrophage phagocytosis index. This study also showed that vitamin A was potential to be developed as a cellular immunomodulator to fight against malaria with the optimal dose is 6 000 IU." @default.
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• W2438053132 date "2016-01-01" @default.
• W2438053132 modified "2023-10-14" @default.
• W2438053132 title "Vitamin A modulation toward IL-12, IFN-γ production and macrophage activity in malaria disease" @default.
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• W2438053132 doi "https://doi.org/10.1063/1.4953523" @default.
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