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• W2438139968 endingPage "269" @default.
• W2438139968 startingPage "262" @default.
• W2438139968 abstract "Natural killer (NK) cells become a prominent cell population in the rodent uterus during pregnancy. The mature, heavily granulated form of these cells is rare in virgin or postpartum uteri. Death, migration, or dedifferentiation could account for the disappearance of these cells from late gestation uteri. We asked whether uterine NK cells, also known as granulated metrial gland (GMG) cells, die in situ and if expression of Fas antigen is essential for their death. Late in gestation, fragmentation of nuclear DNA was detected histologically by OH-end labeling, as were ultrastructural changes suggesting cell death. NK cells developed in and were lost from the uteri of pregnant Fas antigen-deficient lpr/lpr mice. Postpartum samples of retained placentas contained some residual NK cells that had moved from regions of uterine musculature toward the uterine lumen and were being expelled with the placenta. Thus, both cell death and placental separation remove NK cells from the peripartum uterus." @default.
• W2438139968 created "2016-06-24" @default.
• W2438139968 creator A5006659747 @default.
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• W2438139968 date "1996-02-01" @default.
• W2438139968 modified "2023-10-16" @default.
• W2438139968 title "Accounting for the peripartum loss of granulated metrial gland cells, a natural killer cell population, from the pregnant mouse uterus" @default.
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• W2438139968 doi "https://doi.org/10.1002/jlb.59.2.262" @default.
• W2438139968 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8603999" @default.
• W2438139968 hasPublicationYear "1996" @default.
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