Matches in SemOpenAlex for { <https://semopenalex.org/work/W2438309014> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W2438309014 endingPage "198" @default.
- W2438309014 startingPage "191" @default.
- W2438309014 abstract "A series of cyclic acetal derivatives of mitomycin C (MC) and porfiromycin (POR) were tested for their ability to kill hypoxic and oxygenated EMT6 tumor cells. Amino methyl acetal and thioacetal substitutions at C-7 of MC and POR dramatically increased the cytotoxicity of the compounds to hypoxic EMT6 tumor cells in vitro but had little effect on the aerobic toxicities. In contrast, a methyl substitution at N1a markedly decreased the aerobic cytotoxicities of the compounds but did not alter the hypoxic cytotoxicities. The POR acetal, BMY-42355, had the largest differential between hypoxic and aerobic cytotoxicities yet observed among MC analogs. Preliminary studies in mice showed that BMY-42355 had good antineoplastic activity when used alone or in combination with radiation and was less toxic than POR; the therapeutic ratio of this compound in these initial studies was higher than those of either MC or POR." @default.
- W2438309014 created "2016-06-24" @default.
- W2438309014 creator A5003259945 @default.
- W2438309014 creator A5005083366 @default.
- W2438309014 creator A5023479145 @default.
- W2438309014 creator A5026170490 @default.
- W2438309014 creator A5043512123 @default.
- W2438309014 creator A5051635822 @default.
- W2438309014 creator A5067569965 @default.
- W2438309014 creator A5074094817 @default.
- W2438309014 date "1991-06-01" @default.
- W2438309014 modified "2023-10-16" @default.
- W2438309014 title "Activity of C-7 Substituted Cyclic Acetal Derivatives of Mitomycin C and Porfiromycin Against Hypoxic and Oxygenated EMT6 Carcinoma Cells <i>In Vitro</i> and <i>In Vivo</i>" @default.
- W2438309014 doi "https://doi.org/10.3727/095535491820873290" @default.
- W2438309014 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2049227" @default.
- W2438309014 hasPublicationYear "1991" @default.
- W2438309014 type Work @default.
- W2438309014 sameAs 2438309014 @default.
- W2438309014 citedByCount "7" @default.
- W2438309014 countsByYear W24383090142012 @default.
- W2438309014 crossrefType "journal-article" @default.
- W2438309014 hasAuthorship W2438309014A5003259945 @default.
- W2438309014 hasAuthorship W2438309014A5005083366 @default.
- W2438309014 hasAuthorship W2438309014A5023479145 @default.
- W2438309014 hasAuthorship W2438309014A5026170490 @default.
- W2438309014 hasAuthorship W2438309014A5043512123 @default.
- W2438309014 hasAuthorship W2438309014A5051635822 @default.
- W2438309014 hasAuthorship W2438309014A5067569965 @default.
- W2438309014 hasAuthorship W2438309014A5074094817 @default.
- W2438309014 hasConcept C109316439 @default.
- W2438309014 hasConcept C141071460 @default.
- W2438309014 hasConcept C150903083 @default.
- W2438309014 hasConcept C185592680 @default.
- W2438309014 hasConcept C202751555 @default.
- W2438309014 hasConcept C207001950 @default.
- W2438309014 hasConcept C2777731525 @default.
- W2438309014 hasConcept C2779338040 @default.
- W2438309014 hasConcept C55493867 @default.
- W2438309014 hasConcept C71240020 @default.
- W2438309014 hasConcept C71924100 @default.
- W2438309014 hasConcept C86803240 @default.
- W2438309014 hasConcept C98274493 @default.
- W2438309014 hasConceptScore W2438309014C109316439 @default.
- W2438309014 hasConceptScore W2438309014C141071460 @default.
- W2438309014 hasConceptScore W2438309014C150903083 @default.
- W2438309014 hasConceptScore W2438309014C185592680 @default.
- W2438309014 hasConceptScore W2438309014C202751555 @default.
- W2438309014 hasConceptScore W2438309014C207001950 @default.
- W2438309014 hasConceptScore W2438309014C2777731525 @default.
- W2438309014 hasConceptScore W2438309014C2779338040 @default.
- W2438309014 hasConceptScore W2438309014C55493867 @default.
- W2438309014 hasConceptScore W2438309014C71240020 @default.
- W2438309014 hasConceptScore W2438309014C71924100 @default.
- W2438309014 hasConceptScore W2438309014C86803240 @default.
- W2438309014 hasConceptScore W2438309014C98274493 @default.
- W2438309014 hasIssue "6" @default.
- W2438309014 hasLocation W24383090141 @default.
- W2438309014 hasLocation W24383090142 @default.
- W2438309014 hasOpenAccess W2438309014 @default.
- W2438309014 hasPrimaryLocation W24383090141 @default.
- W2438309014 hasRelatedWork W1592261125 @default.
- W2438309014 hasRelatedWork W1982027601 @default.
- W2438309014 hasRelatedWork W200909032 @default.
- W2438309014 hasRelatedWork W2083651068 @default.
- W2438309014 hasRelatedWork W2119867810 @default.
- W2438309014 hasRelatedWork W2416964709 @default.
- W2438309014 hasRelatedWork W2464301138 @default.
- W2438309014 hasRelatedWork W2793519975 @default.
- W2438309014 hasRelatedWork W2188252428 @default.
- W2438309014 hasRelatedWork W2410600356 @default.
- W2438309014 hasVolume "3" @default.
- W2438309014 isParatext "false" @default.
- W2438309014 isRetracted "false" @default.
- W2438309014 magId "2438309014" @default.
- W2438309014 workType "article" @default.