Matches in SemOpenAlex for { <https://semopenalex.org/work/W2438355416> ?p ?o ?g. }
- W2438355416 endingPage "391" @default.
- W2438355416 startingPage "371" @default.
- W2438355416 abstract "Estrogen (E2) plays a central role in the development and progression of hormone-responsive cancers. Estrogen metabolites exhibit either stimulatory or inhibitory roles on breast and prostate cells. The catechol metabolite 4-hydroxyestradiol (4-OHE2) enhances cell proliferation, while 2-methoxyestradiol (2 ME) possesses anticancer activity. The major metabolizing enzyme responsible for detoxifying the deleterious metabolite 4-OHE2 and forming the anticancer metabolite 2 ME is Catechol-O-Methyl Transferase (COMT). The current work investigated the relationship between the expression level of COMT and the cell proliferation of hormone-responsive cancers. The results showed that COMT silencing enhanced the cell proliferation of ER-α positive cancer cells MCF-7 and PC-3 but not the cells that lack ER-α expression as MDA-MB231 and DU-145. The data generated from our study provides a better understanding of the effect of COMT on critical signaling pathways involved in the development and progression of breast cancer (BC) and prostate cancer (PC) including ER-α, p21cip1, p27kip1, NF-κB (P65) and CYP19A1. These findings suggest that COMT enzyme plays a tumor suppressor role in hormone receptor-positive tumors which opens the door for future studies to validate COMT expression as a novel biomarker for the prediction of cancer aggressiveness and treatment efficacy." @default.
- W2438355416 created "2016-06-24" @default.
- W2438355416 creator A5009814106 @default.
- W2438355416 creator A5055827164 @default.
- W2438355416 date "1984-06-01" @default.
- W2438355416 modified "2023-10-09" @default.
- W2438355416 title "Erythropoiesis in Culture" @default.
- W2438355416 cites W1245023662 @default.
- W2438355416 cites W1421162947 @default.
- W2438355416 cites W142717830 @default.
- W2438355416 cites W1482139377 @default.
- W2438355416 cites W1502674903 @default.
- W2438355416 cites W1503521438 @default.
- W2438355416 cites W1531716687 @default.
- W2438355416 cites W1541049769 @default.
- W2438355416 cites W1556151368 @default.
- W2438355416 cites W1582693243 @default.
- W2438355416 cites W1585526875 @default.
- W2438355416 cites W1601011680 @default.
- W2438355416 cites W1968541478 @default.
- W2438355416 cites W197015377 @default.
- W2438355416 cites W1971656494 @default.
- W2438355416 cites W1973246964 @default.
- W2438355416 cites W1987366186 @default.
- W2438355416 cites W1990303992 @default.
- W2438355416 cites W1991206650 @default.
- W2438355416 cites W1994005628 @default.
- W2438355416 cites W1997054434 @default.
- W2438355416 cites W2007854431 @default.
- W2438355416 cites W2010550077 @default.
- W2438355416 cites W2011856894 @default.
- W2438355416 cites W2024102310 @default.
- W2438355416 cites W2027788533 @default.
- W2438355416 cites W2030101666 @default.
- W2438355416 cites W2031697682 @default.
- W2438355416 cites W2034523390 @default.
- W2438355416 cites W2040337718 @default.
- W2438355416 cites W2044341955 @default.
- W2438355416 cites W2050540020 @default.
- W2438355416 cites W2060749908 @default.
- W2438355416 cites W2063759625 @default.
- W2438355416 cites W2065577646 @default.
- W2438355416 cites W2076593817 @default.
- W2438355416 cites W2077282947 @default.
- W2438355416 cites W2079165129 @default.
- W2438355416 cites W2081103358 @default.
- W2438355416 cites W2086942851 @default.
- W2438355416 cites W2088082583 @default.
- W2438355416 cites W2089626710 @default.
- W2438355416 cites W2100323385 @default.
- W2438355416 cites W2100406695 @default.
- W2438355416 cites W2101601310 @default.
- W2438355416 cites W2104022359 @default.
- W2438355416 cites W2106279767 @default.
- W2438355416 cites W2109899235 @default.
- W2438355416 cites W2125665207 @default.
- W2438355416 cites W2126651729 @default.
- W2438355416 cites W2135354962 @default.
- W2438355416 cites W2146256998 @default.
- W2438355416 cites W2152334644 @default.
- W2438355416 cites W2154037033 @default.
- W2438355416 cites W2282290234 @default.
- W2438355416 cites W2293879350 @default.
- W2438355416 cites W2398322608 @default.
- W2438355416 cites W2398880783 @default.
- W2438355416 cites W2402032086 @default.
- W2438355416 cites W2409808097 @default.
- W2438355416 cites W2413031567 @default.
- W2438355416 cites W2416599184 @default.
- W2438355416 cites W2416683008 @default.
- W2438355416 cites W244364670 @default.
- W2438355416 cites W256703290 @default.
- W2438355416 cites W307574227 @default.
- W2438355416 cites W4239145734 @default.
- W2438355416 cites W4249832396 @default.
- W2438355416 cites W84388527 @default.
- W2438355416 doi "https://doi.org/10.1016/s0308-2261(21)00428-8" @default.
- W2438355416 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6432390" @default.
- W2438355416 hasPublicationYear "1984" @default.
- W2438355416 type Work @default.
- W2438355416 sameAs 2438355416 @default.
- W2438355416 citedByCount "101" @default.
- W2438355416 countsByYear W24383554162012 @default.
- W2438355416 countsByYear W24383554162013 @default.
- W2438355416 countsByYear W24383554162018 @default.
- W2438355416 countsByYear W24383554162019 @default.
- W2438355416 crossrefType "journal-article" @default.
- W2438355416 hasAuthorship W2438355416A5009814106 @default.
- W2438355416 hasAuthorship W2438355416A5055827164 @default.
- W2438355416 hasConcept C104317684 @default.
- W2438355416 hasConcept C121608353 @default.
- W2438355416 hasConcept C126322002 @default.
- W2438355416 hasConcept C134018914 @default.
- W2438355416 hasConcept C180754005 @default.
- W2438355416 hasConcept C185361966 @default.
- W2438355416 hasConcept C185592680 @default.
- W2438355416 hasConcept C2776260442 @default.
- W2438355416 hasConcept C2777164284 @default.