FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2438471661> ?p ?o ?g. }

• W2438471661 abstract "Nuclear distribution element-like 1 (NDEL1/NUDEL) is a mammalian homolog of the Aspergillus nidulans nuclear distribution molecule NudE. NDEL1 plays a critical role in neuronal migration, neurite outgrowth and neuronal positioning during brain development; however within the adult central nervous system, limited information is available regarding NDEL1 expression and functions. Here, the goal was to examine inducible NDEL1 expression in the adult mouse forebrain. Immunolabeling revealed NDEL1 within the forebrain, including the cortex and hippocampus, as well as the midbrain and hypothalamus. Expression was principally localized to perikarya. Using a combination of immunolabeling and RNA seq profiling, we detected a marked and long-lasting upregulation of NDEL1 expression within the hippocampus following a pilocarpine-evoked repetitive seizure paradigm. Chromatin immunoprecipitation (ChIP) analysis identified a cAMP response element-binding protein (CREB) binding site within the CpG island proximal to the NDEL1 gene, and in vivo transgenic repression of CREB led to a marked downregulation of seizure-evoked NDEL1 expression. Together these data indicate that NDEL1 is inducibly expressed in the adult nervous system, and that signaling via the CREB/CRE transcriptional pathway is likely involved. The role of NDEL1 in neuronal migration and neurite outgrowth during development raises the interesting prospect that inducible NDEL1 in the mature nervous system could contribute to the well-characterized structural and functional plasticity resulting from repetitive seizure activity." @default.
• W2438471661 created "2016-06-24" @default.
• W2438471661 creator A5004798073 @default.
• W2438471661 creator A5013842386 @default.
• W2438471661 creator A5040448932 @default.
• W2438471661 creator A5071083284 @default.
• W2438471661 creator A5077621462 @default.
• W2438471661 creator A5078139967 @default.
• W2438471661 creator A5086289632 @default.
• W2438471661 creator A5087779277 @default.
• W2438471661 creator A5088931288 @default.
• W2438471661 date "2016-09-01" @default.
• W2438471661 modified "2023-10-15" @default.
• W2438471661 title "Status epilepticus stimulates NDEL1 expression via the CREB/CRE pathway in the adult mouse brain" @default.
• W2438471661 cites W1608481794 @default.
• W2438471661 cites W1764067125 @default.
• W2438471661 cites W1874291746 @default.
• W2438471661 cites W1971095698 @default.
• W2438471661 cites W1973852017 @default.
• W2438471661 cites W1980303046 @default.
• W2438471661 cites W1981017578 @default.
• W2438471661 cites W1982012586 @default.
• W2438471661 cites W1989691334 @default.
• W2438471661 cites W2000040515 @default.
• W2438471661 cites W2000370316 @default.
• W2438471661 cites W2001554877 @default.
• W2438471661 cites W2002287054 @default.
• W2438471661 cites W2003131010 @default.
• W2438471661 cites W2005015111 @default.
• W2438471661 cites W2006777504 @default.
• W2438471661 cites W2011029903 @default.
• W2438471661 cites W2011517712 @default.
• W2438471661 cites W2018219462 @default.
• W2438471661 cites W2023960672 @default.
• W2438471661 cites W2026082145 @default.
• W2438471661 cites W2029524108 @default.
• W2438471661 cites W2029789663 @default.
• W2438471661 cites W2036538226 @default.
• W2438471661 cites W2036623899 @default.
• W2438471661 cites W2037835429 @default.
• W2438471661 cites W2042250385 @default.
• W2438471661 cites W2049069182 @default.
• W2438471661 cites W2050873080 @default.
• W2438471661 cites W2054401541 @default.
• W2438471661 cites W2057051592 @default.
• W2438471661 cites W2060969086 @default.
• W2438471661 cites W2068804211 @default.
• W2438471661 cites W2076948063 @default.
• W2438471661 cites W2077144720 @default.
• W2438471661 cites W2079860596 @default.
• W2438471661 cites W2084748297 @default.
• W2438471661 cites W2085228451 @default.
• W2438471661 cites W2106726734 @default.
• W2438471661 cites W2118608526 @default.
• W2438471661 cites W2120165202 @default.
• W2438471661 cites W2121211805 @default.
• W2438471661 cites W2133748952 @default.
• W2438471661 cites W2134245236 @default.
• W2438471661 cites W2134505334 @default.
• W2438471661 cites W2142616907 @default.
• W2438471661 cites W2147306662 @default.
• W2438471661 cites W2154562317 @default.
• W2438471661 cites W2157752802 @default.
• W2438471661 cites W2159803470 @default.
• W2438471661 cites W2161458853 @default.
• W2438471661 cites W2165343647 @default.
• W2438471661 cites W4211102584 @default.
• W2438471661 cites W51730955 @default.
• W2438471661 doi "https://doi.org/10.1016/j.neuroscience.2016.06.010" @default.
• W2438471661 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5363720" @default.
• W2438471661 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27298008" @default.
• W2438471661 hasPublicationYear "2016" @default.
• W2438471661 type Work @default.
• W2438471661 sameAs 2438471661 @default.
• W2438471661 citedByCount "9" @default.
• W2438471661 countsByYear W24384716612016 @default.
• W2438471661 countsByYear W24384716612020 @default.
• W2438471661 countsByYear W24384716612021 @default.
• W2438471661 countsByYear W24384716612022 @default.
• W2438471661 crossrefType "journal-article" @default.
• W2438471661 hasAuthorship W2438471661A5004798073 @default.
• W2438471661 hasAuthorship W2438471661A5013842386 @default.
• W2438471661 hasAuthorship W2438471661A5040448932 @default.
• W2438471661 hasAuthorship W2438471661A5071083284 @default.
• W2438471661 hasAuthorship W2438471661A5077621462 @default.
• W2438471661 hasAuthorship W2438471661A5078139967 @default.
• W2438471661 hasAuthorship W2438471661A5086289632 @default.
• W2438471661 hasAuthorship W2438471661A5087779277 @default.
• W2438471661 hasAuthorship W2438471661A5088931288 @default.
• W2438471661 hasBestOaLocation W24384716611 @default.
• W2438471661 hasConcept C104317684 @default.
• W2438471661 hasConcept C113246987 @default.
• W2438471661 hasConcept C1629964 @default.
• W2438471661 hasConcept C169760540 @default.
• W2438471661 hasConcept C170493617 @default.
• W2438471661 hasConcept C202751555 @default.
• W2438471661 hasConcept C2779715522 @default.
• W2438471661 hasConcept C2781161787 @default.
• W2438471661 hasConcept C529278444 @default.
• W2438471661 hasConcept C54355233 @default.

• next