Matches in SemOpenAlex for { <https://semopenalex.org/work/W2438983274> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W2438983274 endingPage "18" @default.
- W2438983274 startingPage "204" @default.
- W2438983274 abstract "The methylcholanthrene GR9 tumour is a fibrosarcoma, originated in a BALB/c (H-2d) mouse, composed of different clones (A7, G2, D8, D6, B11, B3, B7, C11, B10, B9) with different class I (Kd Dd Ld) expression. We present data indicating that MHC class I differences observed between the different clones correlated with RNA levels and can be modified with recombinant interferon-gamma. We also studied the presence of tumour-associated antigens in GR9 and their different clones using the monoclonal antibody (MoAb) technology. We produced two syngeneic MoAbs, A7.2 and A7.6, which reacted to GR9 clones. These MoAbs precipitated a 70-kilodalton molecule and did not react with cells positive for the classical Gp70 antigen such as YC-8, LSTRA (H-2d) and RBL-5 (H-2b) lymphomas. A7.2 and A7.6 MoAbs were also negative with normal cells. In this well-characterized tumour model, we analysed the influence of the expression of class I molecules and tumour-associated antigens upon the generation, in vitro and in vivo, of the specific anti-tumour immune response. We produced syngeneic anti-GR9 A7 cytotoxic T lymphocytes (CTLs) which showed significant cytotoxicity against most of the GR9 clones including clones with low or no H-2 class I expression. These CTLs showed no cytotoxic activity against other tumour cells and concanavalin A blasts, neither could the CTL-specific response be inhibited with A7.2 and A7.6 syngeneic MoAbs nor with a panel of anti-class I MoAbs. In vivo experiments have shown that pre-immunization with the immunogenic clone GR9 A7 protects against a challenge of the different GR9 clones, independently of their class I expression and their in vitro susceptibility to lysis by anti-GR9 A7 CTLs. These results demonstrate the existence of cross-reactive tumor-associated transplantation antigens between different clones of the same tumour and the absence of correlation between in vitro susceptibility to lysis and in vivo tumour rejection. Finally, we discuss these results in the context of anti-tumour effector mechanisms generated in chemically induced tumours." @default.
- W2438983274 created "2016-06-24" @default.
- W2438983274 creator A5035391740 @default.
- W2438983274 creator A5037550489 @default.
- W2438983274 creator A5038723665 @default.
- W2438983274 creator A5039496156 @default.
- W2438983274 creator A5042013368 @default.
- W2438983274 creator A5048646773 @default.
- W2438983274 creator A5064535480 @default.
- W2438983274 creator A5088317216 @default.
- W2438983274 date "1989-01-01" @default.
- W2438983274 modified "2023-09-23" @default.
- W2438983274 title "H-2 antigens and tumour-associated transplantation antigens in clones derived from a methylcholanthrene-induced BALB/c tumour: their influence on the generation in vitro and in vivo of the specific anti-tumour immune response." @default.
- W2438983274 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2631798" @default.
- W2438983274 hasPublicationYear "1989" @default.
- W2438983274 type Work @default.
- W2438983274 sameAs 2438983274 @default.
- W2438983274 citedByCount "1" @default.
- W2438983274 crossrefType "journal-article" @default.
- W2438983274 hasAuthorship W2438983274A5035391740 @default.
- W2438983274 hasAuthorship W2438983274A5037550489 @default.
- W2438983274 hasAuthorship W2438983274A5038723665 @default.
- W2438983274 hasAuthorship W2438983274A5039496156 @default.
- W2438983274 hasAuthorship W2438983274A5042013368 @default.
- W2438983274 hasAuthorship W2438983274A5048646773 @default.
- W2438983274 hasAuthorship W2438983274A5064535480 @default.
- W2438983274 hasAuthorship W2438983274A5088317216 @default.
- W2438983274 hasConcept C109316439 @default.
- W2438983274 hasConcept C114246631 @default.
- W2438983274 hasConcept C141071460 @default.
- W2438983274 hasConcept C147483822 @default.
- W2438983274 hasConcept C147969180 @default.
- W2438983274 hasConcept C153911025 @default.
- W2438983274 hasConcept C154317977 @default.
- W2438983274 hasConcept C159654299 @default.
- W2438983274 hasConcept C19869320 @default.
- W2438983274 hasConcept C202751555 @default.
- W2438983274 hasConcept C203014093 @default.
- W2438983274 hasConcept C207001950 @default.
- W2438983274 hasConcept C207936829 @default.
- W2438983274 hasConcept C2776495794 @default.
- W2438983274 hasConcept C2780303067 @default.
- W2438983274 hasConcept C2911091166 @default.
- W2438983274 hasConcept C542903549 @default.
- W2438983274 hasConcept C54355233 @default.
- W2438983274 hasConcept C71924100 @default.
- W2438983274 hasConcept C86803240 @default.
- W2438983274 hasConceptScore W2438983274C109316439 @default.
- W2438983274 hasConceptScore W2438983274C114246631 @default.
- W2438983274 hasConceptScore W2438983274C141071460 @default.
- W2438983274 hasConceptScore W2438983274C147483822 @default.
- W2438983274 hasConceptScore W2438983274C147969180 @default.
- W2438983274 hasConceptScore W2438983274C153911025 @default.
- W2438983274 hasConceptScore W2438983274C154317977 @default.
- W2438983274 hasConceptScore W2438983274C159654299 @default.
- W2438983274 hasConceptScore W2438983274C19869320 @default.
- W2438983274 hasConceptScore W2438983274C202751555 @default.
- W2438983274 hasConceptScore W2438983274C203014093 @default.
- W2438983274 hasConceptScore W2438983274C207001950 @default.
- W2438983274 hasConceptScore W2438983274C207936829 @default.
- W2438983274 hasConceptScore W2438983274C2776495794 @default.
- W2438983274 hasConceptScore W2438983274C2780303067 @default.
- W2438983274 hasConceptScore W2438983274C2911091166 @default.
- W2438983274 hasConceptScore W2438983274C542903549 @default.
- W2438983274 hasConceptScore W2438983274C54355233 @default.
- W2438983274 hasConceptScore W2438983274C71924100 @default.
- W2438983274 hasConceptScore W2438983274C86803240 @default.
- W2438983274 hasIssue "3" @default.
- W2438983274 hasLocation W24389832741 @default.
- W2438983274 hasOpenAccess W2438983274 @default.
- W2438983274 hasPrimaryLocation W24389832741 @default.
- W2438983274 hasRelatedWork W1568056581 @default.
- W2438983274 hasRelatedWork W1964986315 @default.
- W2438983274 hasRelatedWork W1993875521 @default.
- W2438983274 hasRelatedWork W1995789187 @default.
- W2438983274 hasRelatedWork W199672269 @default.
- W2438983274 hasRelatedWork W2028372115 @default.
- W2438983274 hasRelatedWork W2041811834 @default.
- W2438983274 hasRelatedWork W2053177727 @default.
- W2438983274 hasRelatedWork W2119737712 @default.
- W2438983274 hasRelatedWork W2132666039 @default.
- W2438983274 hasVolume "6" @default.
- W2438983274 isParatext "false" @default.
- W2438983274 isRetracted "false" @default.
- W2438983274 magId "2438983274" @default.
- W2438983274 workType "article" @default.