Matches in SemOpenAlex for { <https://semopenalex.org/work/W2439143110> ?p ?o ?g. }
- W2439143110 endingPage "3307" @default.
- W2439143110 startingPage "3296" @default.
- W2439143110 abstract "Bioactive lipids derived from the metabolism of polyunsaturated fatty acids are important mediators of the inflammatory response. Labor per se is considered a sterile inflammatory process. Intra-amniotic inflammation (IAI) due to microorganisms (i.e., intra-amniotic infection) or danger signals (i.e., sterile IAI) has been implicated in the pathogenesis of preterm labor and clinical chorioamnionitis at term. Early and accurate diagnosis of microbial invasion of the amniotic cavity (MIAC) requires analysis of amniotic fluid (AF). It is possible that IAI caused by microorganisms is associated with a stereotypic lipidomic profile, and that analysis of AF may help in the identification of patients with this condition. To test this hypothesis, we analyzed the fatty acyl lipidome of AF by liquid chromatography-mass spectrometry from patients in spontaneous labor at term and preterm gestations. We report that the AF concentrations of proinflammatory lipid mediators of the 5-lipoxygenase pathway are significantly higher in MIAC than in cases of sterile IAI. These results suggest that the concentrations of 5-lipoxygenase metabolites of arachidonic acid, 5-hydroxyeicosatetraenoic acid, and leukotriene B4 in particular could serve as potential biomarkers of MIAC. This finding could have important implications for the rapid identification of patients who may benefit from anti-microbial treatment.-Maddipati, K. R., Romero, R., Chaiworapongsa ,T., Chaemsaithong, P., Zhou, S.-L., Xu, Z., Tarca, A. L., Kusanovic, J. P., Gomez, R., Chaiyasit, N., Honn, K. V. Lipidomic analysis of patients with microbial invasion of the amniotic cavity reveals up-regulation of leukotriene B4." @default.
- W2439143110 created "2016-06-24" @default.
- W2439143110 creator A5000655349 @default.
- W2439143110 creator A5011726013 @default.
- W2439143110 creator A5032961249 @default.
- W2439143110 creator A5043182205 @default.
- W2439143110 creator A5043404288 @default.
- W2439143110 creator A5044817021 @default.
- W2439143110 creator A5056057196 @default.
- W2439143110 creator A5067511554 @default.
- W2439143110 creator A5069136110 @default.
- W2439143110 creator A5078118094 @default.
- W2439143110 creator A5079057191 @default.
- W2439143110 date "2016-06-16" @default.
- W2439143110 modified "2023-09-25" @default.
- W2439143110 title "Lipidomic analysis of patients with microbial invasion of the amniotic cavity reveals up‐regulation of leukotriene B<sub>4</sub>" @default.
- W2439143110 cites W141984575 @default.
- W2439143110 cites W1479290061 @default.
- W2439143110 cites W1486027616 @default.
- W2439143110 cites W1503010799 @default.
- W2439143110 cites W1521347358 @default.
- W2439143110 cites W1563950821 @default.
- W2439143110 cites W1601002338 @default.
- W2439143110 cites W1675122471 @default.
- W2439143110 cites W1750459419 @default.
- W2439143110 cites W1864373603 @default.
- W2439143110 cites W1964610718 @default.
- W2439143110 cites W1965513229 @default.
- W2439143110 cites W1965897259 @default.
- W2439143110 cites W1969090354 @default.
- W2439143110 cites W1971351331 @default.
- W2439143110 cites W1976015795 @default.
- W2439143110 cites W1978818199 @default.
- W2439143110 cites W1986735406 @default.
- W2439143110 cites W1990014836 @default.
- W2439143110 cites W1990137364 @default.
- W2439143110 cites W1990845589 @default.
- W2439143110 cites W1992777534 @default.
- W2439143110 cites W1998377876 @default.
- W2439143110 cites W2004351423 @default.
- W2439143110 cites W2004536682 @default.
- W2439143110 cites W2005762328 @default.
- W2439143110 cites W2007187686 @default.
- W2439143110 cites W2010101647 @default.
- W2439143110 cites W2012794664 @default.
- W2439143110 cites W2021341550 @default.
- W2439143110 cites W2024768515 @default.
- W2439143110 cites W2028315160 @default.
- W2439143110 cites W2032739461 @default.
- W2439143110 cites W2034315903 @default.
- W2439143110 cites W2036819828 @default.
- W2439143110 cites W2041359680 @default.
- W2439143110 cites W2043067747 @default.
- W2439143110 cites W2044563621 @default.
- W2439143110 cites W2050305050 @default.
- W2439143110 cites W2051572583 @default.
- W2439143110 cites W2054067077 @default.
- W2439143110 cites W2055755613 @default.
- W2439143110 cites W2056240857 @default.
- W2439143110 cites W2059799937 @default.
- W2439143110 cites W2064715571 @default.
- W2439143110 cites W2070314236 @default.
- W2439143110 cites W2072696221 @default.
- W2439143110 cites W2074894196 @default.
- W2439143110 cites W2076798898 @default.
- W2439143110 cites W2077036031 @default.
- W2439143110 cites W2077221155 @default.
- W2439143110 cites W2083400097 @default.
- W2439143110 cites W2087800038 @default.
- W2439143110 cites W2088357936 @default.
- W2439143110 cites W2092077411 @default.
- W2439143110 cites W2092305714 @default.
- W2439143110 cites W2092801734 @default.
- W2439143110 cites W2093277404 @default.
- W2439143110 cites W2093782142 @default.
- W2439143110 cites W2094950835 @default.
- W2439143110 cites W2095254657 @default.
- W2439143110 cites W2103010344 @default.
- W2439143110 cites W2103335729 @default.
- W2439143110 cites W2108813933 @default.
- W2439143110 cites W2108983412 @default.
- W2439143110 cites W2110065044 @default.
- W2439143110 cites W2113203684 @default.
- W2439143110 cites W2117598587 @default.
- W2439143110 cites W2118340704 @default.
- W2439143110 cites W2120276871 @default.
- W2439143110 cites W2121636839 @default.
- W2439143110 cites W2122267267 @default.
- W2439143110 cites W2125166909 @default.
- W2439143110 cites W2129935236 @default.
- W2439143110 cites W2132739313 @default.
- W2439143110 cites W2134056170 @default.
- W2439143110 cites W2148536296 @default.
- W2439143110 cites W2150982004 @default.
- W2439143110 cites W2151876139 @default.
- W2439143110 cites W2154064379 @default.
- W2439143110 cites W2159913536 @default.
- W2439143110 cites W2179950617 @default.