Matches in SemOpenAlex for { <https://semopenalex.org/work/W2439189166> ?p ?o ?g. }
- W2439189166 endingPage "905" @default.
- W2439189166 startingPage "893" @default.
- W2439189166 abstract "Recently, aging societies have been showing an increasingly strong relationship between Alzheimer’s disease (AD) and chronic cerebral hypoperfusion (HP). In the present study, we created a new mouse model for AD with HP, and investigated its clinical and pathological characteristics. Alzheimer’s di sease transgenic mice (APP23) were subjected to bilateral common carotid arteries stenosis with ameroid constrictors for slowly progressive cerebral HP. In contrast to simple APP23 mice, cerebral HP exacerbated motor and cognitive dysfunctions with white matter lesions and meningo-parenchymal amyloid-β (Aβ) burdens. Strong cerebrovascular inflammation and severe amyloid angiopathy with cerebrovascular remodeling were also observed in APP23 + HP mouse brains. An acetylcholinesterase inhibitor galantamine improved such clinical dysfunctions, retrieved above neuropathological characteristics, and enhanced nicotinic acetylcholine receptor (nAChR)-binding activity. The present study demonstrates that chronic cerebral HP enhanced cognitive/motor dysfunctions with parenchymal/cerebrovascular Aβ accumulation and cerebrovascular remodeling. These neuropathological abnormalities were greatly ameliorated by galantamine treatment associated with nAChR-mediated neuroprotection by allosterically potentiating ligand action." @default.
- W2439189166 created "2016-06-24" @default.
- W2439189166 creator A5017019982 @default.
- W2439189166 creator A5035104179 @default.
- W2439189166 creator A5035378056 @default.
- W2439189166 creator A5038750531 @default.
- W2439189166 creator A5053032316 @default.
- W2439189166 creator A5058675749 @default.
- W2439189166 creator A5067675564 @default.
- W2439189166 creator A5071521060 @default.
- W2439189166 creator A5072735319 @default.
- W2439189166 creator A5078710220 @default.
- W2439189166 creator A5079355966 @default.
- W2439189166 date "2016-08-03" @default.
- W2439189166 modified "2023-10-11" @default.
- W2439189166 title "Chronic Cerebral Hypoperfusion Accelerates Alzheimer’s Disease Pathology with Cerebrovascular Remodeling in a Novel Mouse Model" @default.
- W2439189166 cites W1528383660 @default.
- W2439189166 cites W1548982997 @default.
- W2439189166 cites W1587950891 @default.
- W2439189166 cites W1619610860 @default.
- W2439189166 cites W1643525023 @default.
- W2439189166 cites W1725786820 @default.
- W2439189166 cites W1803418897 @default.
- W2439189166 cites W1918799378 @default.
- W2439189166 cites W1968903370 @default.
- W2439189166 cites W1979221664 @default.
- W2439189166 cites W1979536811 @default.
- W2439189166 cites W1980275236 @default.
- W2439189166 cites W1983670592 @default.
- W2439189166 cites W1983912064 @default.
- W2439189166 cites W1992688322 @default.
- W2439189166 cites W1994202817 @default.
- W2439189166 cites W1994609866 @default.
- W2439189166 cites W1995344309 @default.
- W2439189166 cites W1996736279 @default.
- W2439189166 cites W1998877458 @default.
- W2439189166 cites W2002924145 @default.
- W2439189166 cites W2011198398 @default.
- W2439189166 cites W2018317802 @default.
- W2439189166 cites W2020834255 @default.
- W2439189166 cites W2021667660 @default.
- W2439189166 cites W2032920422 @default.
- W2439189166 cites W2036288989 @default.
- W2439189166 cites W2040571516 @default.
- W2439189166 cites W2040934693 @default.
- W2439189166 cites W2042902316 @default.
- W2439189166 cites W2043170711 @default.
- W2439189166 cites W2043467860 @default.
- W2439189166 cites W2044456875 @default.
- W2439189166 cites W2045836468 @default.
- W2439189166 cites W2047731623 @default.
- W2439189166 cites W2050556307 @default.
- W2439189166 cites W2053099665 @default.
- W2439189166 cites W2063933455 @default.
- W2439189166 cites W2072023765 @default.
- W2439189166 cites W2073295417 @default.
- W2439189166 cites W2084675121 @default.
- W2439189166 cites W2089189236 @default.
- W2439189166 cites W2108196559 @default.
- W2439189166 cites W2113965122 @default.
- W2439189166 cites W2114789645 @default.
- W2439189166 cites W2120197600 @default.
- W2439189166 cites W2131100828 @default.
- W2439189166 cites W2131385187 @default.
- W2439189166 cites W2137324084 @default.
- W2439189166 cites W2141035202 @default.
- W2439189166 cites W2141411849 @default.
- W2439189166 cites W2150520466 @default.
- W2439189166 cites W2156220037 @default.
- W2439189166 cites W2165773859 @default.
- W2439189166 cites W2463189234 @default.
- W2439189166 doi "https://doi.org/10.3233/jad-160345" @default.
- W2439189166 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27314529" @default.
- W2439189166 hasPublicationYear "2016" @default.
- W2439189166 type Work @default.
- W2439189166 sameAs 2439189166 @default.
- W2439189166 citedByCount "35" @default.
- W2439189166 countsByYear W24391891662017 @default.
- W2439189166 countsByYear W24391891662018 @default.
- W2439189166 countsByYear W24391891662019 @default.
- W2439189166 countsByYear W24391891662020 @default.
- W2439189166 countsByYear W24391891662021 @default.
- W2439189166 countsByYear W24391891662022 @default.
- W2439189166 crossrefType "journal-article" @default.
- W2439189166 hasAuthorship W2439189166A5017019982 @default.
- W2439189166 hasAuthorship W2439189166A5035104179 @default.
- W2439189166 hasAuthorship W2439189166A5035378056 @default.
- W2439189166 hasAuthorship W2439189166A5038750531 @default.
- W2439189166 hasAuthorship W2439189166A5053032316 @default.
- W2439189166 hasAuthorship W2439189166A5058675749 @default.
- W2439189166 hasAuthorship W2439189166A5067675564 @default.
- W2439189166 hasAuthorship W2439189166A5071521060 @default.
- W2439189166 hasAuthorship W2439189166A5072735319 @default.
- W2439189166 hasAuthorship W2439189166A5078710220 @default.
- W2439189166 hasAuthorship W2439189166A5079355966 @default.
- W2439189166 hasConcept C126322002 @default.
- W2439189166 hasConcept C127413603 @default.
- W2439189166 hasConcept C142724271 @default.