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• W2439310419 endingPage "1081" @default.
• W2439310419 startingPage "1074" @default.
• W2439310419 abstract "Cytochrome P450 (CYP) 3A polymorphisms are associated with variable CYP3A metabolizing enzyme activity and tacrolimus pharmacokinetics. We sought to determine the singular and combined impact of CYP3A4*22 and CYP3A5*3 variants on tacrolimus drug disposition in adult heart transplant recipients.The retrospective study included 76 patients greater than one year post-heart transplant and receiving tacrolimus. Patients were genotyped for CYP3A4*22 and CYP3A5*3, and combined genotypes were classified as follows: extensive metabolizers (EM, CYP3A4*1/*1+CYP3A5*1 carriers), intermediate metabolizers (IM, CYP3A4*1/*1+CYP3A5*3/*3, or CYP3A4*22 carriers+CYP3A5*1 carriers), and poor metabolizers (PM, CYP3A4*22 carriers+CYP3A5*3/*3). The primary outcome was tacrolimus dose-adjusted trough concentration (C0 /D, ng/mL per mg/d).In singular analysis, tacrolimus C0 /D did not differ significantly between CYP3A4*22 genotype groups. However, tacrolimus C0 /D was 1.8-fold lower (P<.001) in CYP3A5 expressers vs non-expressers. When combined CYP3A genotypes were evaluated, tacrolimus C0 /D was 1.8-fold lower in EMs vs IMs (P<.001) and EMs vs PMs (P=.001). Tacrolimus C0 /D did not differ significantly between CYP3A IMs vs PMs.Combined CYP3A genotype was associated with tacrolimus drug disposition in adult heart transplant recipients, but the effect was largely driven by CYP3A5*3. These data suggest that CYP3A4*22 and combined CYP3A genotypes are unlikely to provide additional information beyond CYP3A5 genotype." @default.
• W2439310419 created "2016-06-24" @default.
• W2439310419 creator A5001550052 @default.
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• W2439310419 date "2016-07-11" @default.
• W2439310419 modified "2023-09-26" @default.
• W2439310419 title "<i>CYP3A</i>pharmacogenetics and tacrolimus disposition in adult heart transplant recipients" @default.
• W2439310419 cites W1683673855 @default.
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• W2439310419 doi "https://doi.org/10.1111/ctr.12790" @default.
• W2439310419 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27314545" @default.
• W2439310419 hasPublicationYear "2016" @default.
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