FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2439478085> ?p ?o ?g. }

• W2439478085 endingPage "44643" @default.
• W2439478085 startingPage "44630" @default.
• W2439478085 abstract "// Hong Yang 1, 2, * , Chang Liu 1, 2, * , Rong-Mei Zhou 1, 2, * , Jin Yao 1, 2, * , Xiu-Miao Li 1 , Yi Shen 1 , Hong Cheng 3 , Jun Yuan 4 , Biao Yan 2 , Qin Jiang 1, 2 1 Eye Hospital, Nanjing Medical University, Nanjing, China 2 The Fourth School of Clinical Medicine, Nanjing Medical University, Nanjing, China 3 Department of Neurology, Jiangsu Province Hospital, Nanjing, China 4 Department of Neurology, Jiangsu Chinese Medicine Hospital, Nanjing, China * These authors have contributed equally to this work Correspondence to: Qin Jiang, email: jqin710@vip.sina.com Biao Yan, email: yanbiao1982@126.com Keywords: tumor angiogenesis, Piezo2, vascular permeability, endothelial cell Received: February 29, 2016      Accepted: May 29, 2016      Published: June 17, 2016 ABSTRACT Angiogenesis is important for invasive tumor growth and metastasis. Its inhibition is a promising tactic for limiting tumor progression. Here, we showed that Piezo2 knockdown led to decreased glioma angiogenesis and reduced vascular hyperpermeability. Piezo2 was highly expressed in tumor endothelial cells, and its knockdown suppressed vascular leakage and tumor angiogenesis. In a retinal vasculature development assay, corneal angiogenesis assay and a modified Miles assay, Piezo2 knockdown obviously decreased angiogenesis and vascular hyperpermeability. In vitro assays revealed that Piezo2 knockdown inhibited endothelial cell proliferation, migration, and tube formation. Moreover, In vitro co-culture system assay showed that Piezo2 knockdown in endothelial cells suppressed cell proliferation, migration, and invasion of glioma tumor cells. Piezo2 could regulate glioma angiogenesis via Ca 2+ /Wnt11/β-catenin signaling in endothelial cells. Taken together, these studies provide the evidence for Piezo2 as a critical regulator of tumor angiogenesis and vascular permeability." @default.
• W2439478085 created "2016-06-24" @default.
• W2439478085 creator A5002252581 @default.
• W2439478085 creator A5022256556 @default.
• W2439478085 creator A5027833732 @default.
• W2439478085 creator A5031957363 @default.
• W2439478085 creator A5035918316 @default.
• W2439478085 creator A5037591628 @default.
• W2439478085 creator A5049393312 @default.
• W2439478085 creator A5049723397 @default.
• W2439478085 creator A5058212805 @default.
• W2439478085 creator A5058567619 @default.
• W2439478085 date "2016-06-17" @default.
• W2439478085 modified "2023-10-01" @default.
• W2439478085 title "Piezo2 protein: A novel regulator of tumor angiogenesis and hyperpermeability" @default.
• W2439478085 cites W1512072225 @default.
• W2439478085 cites W175938947 @default.
• W2439478085 cites W1972502063 @default.
• W2439478085 cites W1975058097 @default.
• W2439478085 cites W1975216289 @default.
• W2439478085 cites W1976176467 @default.
• W2439478085 cites W1987139248 @default.
• W2439478085 cites W1992112921 @default.
• W2439478085 cites W1999720993 @default.
• W2439478085 cites W2000617404 @default.
• W2439478085 cites W2006419043 @default.
• W2439478085 cites W2012063336 @default.
• W2439478085 cites W2020423449 @default.
• W2439478085 cites W2027880075 @default.
• W2439478085 cites W2030445517 @default.
• W2439478085 cites W2048492290 @default.
• W2439478085 cites W2054088330 @default.
• W2439478085 cites W2066905281 @default.
• W2439478085 cites W2068757005 @default.
• W2439478085 cites W2077807460 @default.
• W2439478085 cites W2083824794 @default.
• W2439478085 cites W2099153170 @default.
• W2439478085 cites W2101671061 @default.
• W2439478085 cites W2104866423 @default.
• W2439478085 cites W2105238625 @default.
• W2439478085 cites W2106271145 @default.
• W2439478085 cites W2112431117 @default.
• W2439478085 cites W2140667637 @default.
• W2439478085 cites W2143852804 @default.
• W2439478085 cites W2146590089 @default.
• W2439478085 cites W2146812359 @default.
• W2439478085 cites W2158021558 @default.
• W2439478085 cites W2161535250 @default.
• W2439478085 cites W2168202400 @default.
• W2439478085 cites W2425314575 @default.
• W2439478085 cites W882982235 @default.
• W2439478085 doi "https://doi.org/10.18632/oncotarget.10134" @default.
• W2439478085 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5190124" @default.
• W2439478085 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27329839" @default.
• W2439478085 hasPublicationYear "2016" @default.
• W2439478085 type Work @default.
• W2439478085 sameAs 2439478085 @default.
• W2439478085 citedByCount "42" @default.
• W2439478085 countsByYear W24394780852016 @default.
• W2439478085 countsByYear W24394780852017 @default.
• W2439478085 countsByYear W24394780852018 @default.
• W2439478085 countsByYear W24394780852019 @default.
• W2439478085 countsByYear W24394780852020 @default.
• W2439478085 countsByYear W24394780852021 @default.
• W2439478085 countsByYear W24394780852022 @default.
• W2439478085 countsByYear W24394780852023 @default.
• W2439478085 crossrefType "journal-article" @default.
• W2439478085 hasAuthorship W2439478085A5002252581 @default.
• W2439478085 hasAuthorship W2439478085A5022256556 @default.
• W2439478085 hasAuthorship W2439478085A5027833732 @default.
• W2439478085 hasAuthorship W2439478085A5031957363 @default.
• W2439478085 hasAuthorship W2439478085A5035918316 @default.
• W2439478085 hasAuthorship W2439478085A5037591628 @default.
• W2439478085 hasAuthorship W2439478085A5049393312 @default.
• W2439478085 hasAuthorship W2439478085A5049723397 @default.
• W2439478085 hasAuthorship W2439478085A5058212805 @default.
• W2439478085 hasAuthorship W2439478085A5058567619 @default.
• W2439478085 hasBestOaLocation W24394780851 @default.
• W2439478085 hasConcept C123012128 @default.
• W2439478085 hasConcept C173396325 @default.
• W2439478085 hasConcept C202751555 @default.
• W2439478085 hasConcept C2778227246 @default.
• W2439478085 hasConcept C2780394083 @default.
• W2439478085 hasConcept C502942594 @default.
• W2439478085 hasConcept C54355233 @default.
• W2439478085 hasConcept C556039675 @default.
• W2439478085 hasConcept C71924100 @default.
• W2439478085 hasConcept C81885089 @default.
• W2439478085 hasConcept C86803240 @default.
• W2439478085 hasConceptScore W2439478085C123012128 @default.
• W2439478085 hasConceptScore W2439478085C173396325 @default.
• W2439478085 hasConceptScore W2439478085C202751555 @default.
• W2439478085 hasConceptScore W2439478085C2778227246 @default.
• W2439478085 hasConceptScore W2439478085C2780394083 @default.
• W2439478085 hasConceptScore W2439478085C502942594 @default.
• W2439478085 hasConceptScore W2439478085C54355233 @default.
• W2439478085 hasConceptScore W2439478085C556039675 @default.
• W2439478085 hasConceptScore W2439478085C71924100 @default.

• next