FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2439565516> ?p ?o ?g. }

• W2439565516 endingPage "2107" @default.
• W2439565516 startingPage "2097" @default.
• W2439565516 abstract "The mechanism of blood-brain barrier (BBB) disruption, involved in poststroke edema and hemorrhagic transformation, is important but elusive. We investigated microRNA-150 (miR-150)-mediated mechanism in the disruption of BBB after stroke in rats. We found that up-regulation of miR-150 increased permeability of BBB as detected by MRI after permanent middle cerebral artery occlusion in vivo as well as increased permeability of brain microvascular endothelial cells after oxygen-glucose deprivation in vitro. The expression of claudin-5, a key tight junction protein, was decreased in the ischemic boundary zone after up-regulation of miR-150. We found in brain microvascular endothelial cells that overexpression of miR-150 decreased not only cell survival rate but also the expression levels of claudin-5 after oxygen-glucose deprivation. With dual-luciferase assay, we confirmed that miR-150 could directly regulate the angiopoietin receptor Tie-2. Moreover, silencing Tie-2 with lentivirus-delivered small interfering RNA reversed the effect of miR-150 on endothelial permeability, cell survival, and claudin-5 expression. Furthermore, poststroke treatment with antagomir-150, a specific miR-150 antagonist, contributed to BBB protection, infarct volume reduction, and amelioration of neurologic deficits. Collectively, our findings suggested that miR-150 could regulate claudin-5 expression and endothelial cell survival by targeting Tie-2, thus affecting the permeability of BBB after permanent middle cerebral artery occlusion in rats, and that miR-150 might be a potential alternative target for the treatment of stroke.-Fang, Z., He, Q.-W., Li, Q., Chen, X.-L., Baral, S., Jin, H.-J., Zhu, Y.-Y., Li, M., Xia, Y.-P., Mao, L., Hu, B. MicroRNA-150 regulates blood-brain barrier permeability via Tie-2 after permanent middle cerebral artery occlusion in rats." @default.
• W2439565516 created "2016-06-24" @default.
• W2439565516 creator A5006734524 @default.
• W2439565516 creator A5011753287 @default.
• W2439565516 creator A5011874331 @default.
• W2439565516 creator A5014942240 @default.
• W2439565516 creator A5015655065 @default.
• W2439565516 creator A5016826534 @default.
• W2439565516 creator A5036866121 @default.
• W2439565516 creator A5040995050 @default.
• W2439565516 creator A5053985637 @default.
• W2439565516 creator A5070704734 @default.
• W2439565516 creator A5080915151 @default.
• W2439565516 date "2016-02-17" @default.
• W2439565516 modified "2023-10-15" @default.
• W2439565516 title "MicroRNA‐150 regulates blood‐brain barrier permeability <i>via</i> Tie‐2 after permanent middle cerebral artery occlusion in rats" @default.
• W2439565516 cites W1495151309 @default.
• W2439565516 cites W1533490577 @default.
• W2439565516 cites W1563575450 @default.
• W2439565516 cites W1923876837 @default.
• W2439565516 cites W1971341676 @default.
• W2439565516 cites W1982355800 @default.
• W2439565516 cites W1982733955 @default.
• W2439565516 cites W1992112921 @default.
• W2439565516 cites W1999508205 @default.
• W2439565516 cites W2000295322 @default.
• W2439565516 cites W2004872316 @default.
• W2439565516 cites W2006874319 @default.
• W2439565516 cites W2008518851 @default.
• W2439565516 cites W2015615473 @default.
• W2439565516 cites W2019839655 @default.
• W2439565516 cites W2027733168 @default.
• W2439565516 cites W2028927776 @default.
• W2439565516 cites W2034941414 @default.
• W2439565516 cites W2037943855 @default.
• W2439565516 cites W2045228120 @default.
• W2439565516 cites W2052307176 @default.
• W2439565516 cites W2058134060 @default.
• W2439565516 cites W2060481603 @default.
• W2439565516 cites W2066834504 @default.
• W2439565516 cites W2066888615 @default.
• W2439565516 cites W2067974738 @default.
• W2439565516 cites W2070651992 @default.
• W2439565516 cites W2081596239 @default.
• W2439565516 cites W2125622673 @default.
• W2439565516 cites W2134387783 @default.
• W2439565516 cites W2140459348 @default.
• W2439565516 cites W2140958279 @default.
• W2439565516 cites W2141852514 @default.
• W2439565516 cites W2142139829 @default.
• W2439565516 cites W2151473756 @default.
• W2439565516 cites W2157087666 @default.
• W2439565516 cites W2169538397 @default.
• W2439565516 cites W2182645989 @default.
• W2439565516 cites W2468923595 @default.
• W2439565516 doi "https://doi.org/10.1096/fj.201500126" @default.
• W2439565516 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26887441" @default.
• W2439565516 hasPublicationYear "2016" @default.
• W2439565516 type Work @default.
• W2439565516 sameAs 2439565516 @default.
• W2439565516 citedByCount "68" @default.
• W2439565516 countsByYear W24395655162016 @default.
• W2439565516 countsByYear W24395655162017 @default.
• W2439565516 countsByYear W24395655162018 @default.
• W2439565516 countsByYear W24395655162019 @default.
• W2439565516 countsByYear W24395655162020 @default.
• W2439565516 countsByYear W24395655162021 @default.
• W2439565516 countsByYear W24395655162022 @default.
• W2439565516 countsByYear W24395655162023 @default.
• W2439565516 crossrefType "journal-article" @default.
• W2439565516 hasAuthorship W2439565516A5006734524 @default.
• W2439565516 hasAuthorship W2439565516A5011753287 @default.
• W2439565516 hasAuthorship W2439565516A5011874331 @default.
• W2439565516 hasAuthorship W2439565516A5014942240 @default.
• W2439565516 hasAuthorship W2439565516A5015655065 @default.
• W2439565516 hasAuthorship W2439565516A5016826534 @default.
• W2439565516 hasAuthorship W2439565516A5036866121 @default.
• W2439565516 hasAuthorship W2439565516A5040995050 @default.
• W2439565516 hasAuthorship W2439565516A5053985637 @default.
• W2439565516 hasAuthorship W2439565516A5070704734 @default.
• W2439565516 hasAuthorship W2439565516A5080915151 @default.
• W2439565516 hasBestOaLocation W24395655161 @default.
• W2439565516 hasConcept C104317684 @default.
• W2439565516 hasConcept C119056186 @default.
• W2439565516 hasConcept C123012128 @default.
• W2439565516 hasConcept C126322002 @default.
• W2439565516 hasConcept C145059251 @default.
• W2439565516 hasConcept C177779419 @default.
• W2439565516 hasConcept C185592680 @default.
• W2439565516 hasConcept C202751555 @default.
• W2439565516 hasConcept C22615655 @default.
• W2439565516 hasConcept C2777649898 @default.
• W2439565516 hasConcept C2778402981 @default.
• W2439565516 hasConcept C2779368916 @default.
• W2439565516 hasConcept C51872919 @default.
• W2439565516 hasConcept C529278444 @default.
• W2439565516 hasConcept C54009773 @default.
• W2439565516 hasConcept C54355233 @default.

• next