Matches in SemOpenAlex for { <https://semopenalex.org/work/W2439765834> ?p ?o ?g. }
Showing items 1 to 65 of
65
with 100 items per page.
- W2439765834 abstract "The synaptic tagging hypothesis explains how input specificity is preserved inlong-term potentiation of synapses. This phenomenon requires new proteins that aresynthesized in the nuclei and shipped cell wide, to be captured by a tag at synapses thatsignal a prior synaptic activity. One specific molecule called calcium/calmodulin KinaseII (CaMKII) plays a major role and has been postulated to function as a synaptic tag dueto its unique properties. The behavioral relevance of synaptic tagging has not beenextensively studied. Using an early odor-preference learning model, which occurs in aweek-old rat pup when a novel odor is paired with a reward, we tested the hypothesis thatCaMKII activation is critical for short and long-term memories as well as for inputspecificityof the odor learning. Using behavioral pharmacology, we first tested whetherblocking CaMKII with KN-62 infusion in the olfactory bulb blocks short-term (tested at 3hr) and long-term memories (tested at 24 hr). Our results show that both memories wereblocked. To test the role of CaMKII in input specificity of long-term memory, we used aPKA agonist, Sp-cAMP, to induce 24 hr memory and tested whether blocking CaMKII atthe same time affects memories for the learned odor (peppermint) as well as a controlodor (vanillin). Co-infusion of Sp-cAMP with KN-62 did not impair 24 hr memory forpeppermint; however, the input specificity was lost since animals also showed preferenceto vanillin. Immunohistochemistry results show that phosphorylated CaMKII is primarilyexpressed in mitral cell dendrites of olfactory bulbs. These experiments help usunderstand the specific role of CaMKII in short and long-term odor memories, its role asa synaptic tag, and its role in memory specificity." @default.
- W2439765834 created "2016-06-24" @default.
- W2439765834 creator A5059709949 @default.
- W2439765834 date "2015-10-01" @default.
- W2439765834 modified "2023-09-27" @default.
- W2439765834 title "CaMKII mediates input-specific early odor preference learning in rats" @default.
- W2439765834 hasPublicationYear "2015" @default.
- W2439765834 type Work @default.
- W2439765834 sameAs 2439765834 @default.
- W2439765834 citedByCount "0" @default.
- W2439765834 crossrefType "dissertation" @default.
- W2439765834 hasAuthorship W2439765834A5059709949 @default.
- W2439765834 hasConcept C130959647 @default.
- W2439765834 hasConcept C15744967 @default.
- W2439765834 hasConcept C163214680 @default.
- W2439765834 hasConcept C169760540 @default.
- W2439765834 hasConcept C170493617 @default.
- W2439765834 hasConcept C185592680 @default.
- W2439765834 hasConcept C201792869 @default.
- W2439765834 hasConcept C25274449 @default.
- W2439765834 hasConcept C2778916471 @default.
- W2439765834 hasConcept C2780496858 @default.
- W2439765834 hasConcept C529278444 @default.
- W2439765834 hasConcept C55493867 @default.
- W2439765834 hasConcept C86803240 @default.
- W2439765834 hasConceptScore W2439765834C130959647 @default.
- W2439765834 hasConceptScore W2439765834C15744967 @default.
- W2439765834 hasConceptScore W2439765834C163214680 @default.
- W2439765834 hasConceptScore W2439765834C169760540 @default.
- W2439765834 hasConceptScore W2439765834C170493617 @default.
- W2439765834 hasConceptScore W2439765834C185592680 @default.
- W2439765834 hasConceptScore W2439765834C201792869 @default.
- W2439765834 hasConceptScore W2439765834C25274449 @default.
- W2439765834 hasConceptScore W2439765834C2778916471 @default.
- W2439765834 hasConceptScore W2439765834C2780496858 @default.
- W2439765834 hasConceptScore W2439765834C529278444 @default.
- W2439765834 hasConceptScore W2439765834C55493867 @default.
- W2439765834 hasConceptScore W2439765834C86803240 @default.
- W2439765834 hasLocation W24397658341 @default.
- W2439765834 hasOpenAccess W2439765834 @default.
- W2439765834 hasPrimaryLocation W24397658341 @default.
- W2439765834 hasRelatedWork W1574126477 @default.
- W2439765834 hasRelatedWork W1986887342 @default.
- W2439765834 hasRelatedWork W1997551208 @default.
- W2439765834 hasRelatedWork W2009030825 @default.
- W2439765834 hasRelatedWork W2021235911 @default.
- W2439765834 hasRelatedWork W2051890594 @default.
- W2439765834 hasRelatedWork W2056815371 @default.
- W2439765834 hasRelatedWork W2081246158 @default.
- W2439765834 hasRelatedWork W2124928155 @default.
- W2439765834 hasRelatedWork W2126616110 @default.
- W2439765834 hasRelatedWork W2128660982 @default.
- W2439765834 hasRelatedWork W2154936764 @default.
- W2439765834 hasRelatedWork W2159279126 @default.
- W2439765834 hasRelatedWork W2221779946 @default.
- W2439765834 hasRelatedWork W22608693 @default.
- W2439765834 hasRelatedWork W2388607874 @default.
- W2439765834 hasRelatedWork W2758121911 @default.
- W2439765834 hasRelatedWork W2945918087 @default.
- W2439765834 hasRelatedWork W2982653701 @default.
- W2439765834 hasRelatedWork W43073654 @default.
- W2439765834 isParatext "false" @default.
- W2439765834 isRetracted "false" @default.
- W2439765834 magId "2439765834" @default.
- W2439765834 workType "dissertation" @default.