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• W2439877177 abstract "Label-free, real-time, and in-situ measurement on cell apoptosis is highly desirable in cell biology. We propose here a design of terahertz (THz) metamaterial-based biosensor for meeting this requirement. This metamaterial consists of a planar array of five concentric subwavelength gold ring resonators on a 10 μm-thick polyimide substrate, which can sense the change of dielectric environment above the metamaterial. We employ this sensor to an oral cancer cell (SCC4) with and without cisplatin, a chemotherapy drug for cancer treatment, and find a linear relation between cell apoptosis measured by Flow Cytometry and the relative change of resonant frequencies of the metamaterial measured by THz time-domain spectroscopy. This implies that we can determine the cell apoptosis in a label-free manner. We believe that this metamaterial-based biosensor can be developed into a cheap, label-free, real-time, and in-situ detection tool, which is of significant impact on the study of cell biology." @default.
• W2439877177 created "2016-06-24" @default.
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• W2439877177 date "2016-06-13" @default.
• W2439877177 modified "2023-10-16" @default.
• W2439877177 title "Label-free measurements on cell apoptosis using a terahertz metamaterial-based biosensor" @default.
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• W2439877177 doi "https://doi.org/10.1063/1.4954015" @default.
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