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- W2439955832 abstract "Hormone receptor positive breast cancer patients have relatively good prognosis after tamoxifen treatment but still about 40% of patients experience treatment failure (1). Recently microRNAs (miRNAs) have been spotlighted as a new biomarker for predicting prognosis and treatment response. The purpose of this study is to identify microRNAs (miRNAs) that related with distant recurrence after tamoxifen and standard treatment and then build an early recurrence prediction model. Methods: Our study measured the expression of 5 miRNAs (miR-134, miR-125b-5P, miRNA-30a, miR-10a-5p, and miR-222) that are selected as a tamoxifen resistant related miRNA by previous micro-array experiment and paper review. 176 FFPE tumor tissues of 176 patients who have hormone receptor positive breast cancer with tamoxifen were measured miRNA expression by quantitative real-time PCR (qRT-PCR). Results: We identified all 5 miRNAs are up-regulated in distant recurrence cases within 5 years after surgery. Other clinico-pathological parameters that are tumor grade, pathologic stage, HER2 statue and P53 status didn9t have any specific correlation with expression of miRNAs. The results suggest that distant recurrence during tamoxifen treatment might be affected by tamoxifen resistant related miRNAs. Kaplan-Meier survival analyses based on expression cut-offs determined by receiver characteristics curves show high expression of miR-134, miR-125b-5P, miRNA-30a, miR-10a-5p, and miR-222 were associated with short relapse-free time(log-rank P = 0.006, P Citation Format: Aeree Kim, Chungyeul Kim. Recurrence prediction model using microRNA expression in hormone receptor positive and tamoxifen treated breast cancer. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 3980. doi:10.1158/1538-7445.AM2015-3980" @default.
- W2439955832 created "2016-06-24" @default.
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- W2439955832 date "2015-08-01" @default.
- W2439955832 modified "2023-09-26" @default.
- W2439955832 title "Abstract 3980: Recurrence prediction model using microRNA expression in hormone receptor positive and tamoxifen treated breast cancer" @default.
- W2439955832 doi "https://doi.org/10.1158/1538-7445.am2015-3980" @default.
- W2439955832 hasPublicationYear "2015" @default.
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