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- W2440181709 endingPage "57" @default.
- W2440181709 startingPage "57" @default.
- W2440181709 abstract "Renal cell carcinoma (RCC) accounts for 90% of all kidney cancers. Due to poor diagnosis, high resistance to the systemic therapies and the fact that most RCC cases occur sporadically, current research switched its focus on studying the molecular mechanisms underlying RCC. The aim is the discovery of new effective and less toxic anti-cancer drugs and novel diagnostic markers. Besides the PI3K/Akt/mTOR, HGF/Met and VHL/hypoxia cellular signaling pathways, the involvement of the Wnt/β-catenin pathway in RCC is commonly studied. Wnt signaling and its targeted genes are known to actively participate in different biological processes during embryonic development and renal cancer. Recently, studies have shown that targeting this pathway by alternating/inhibiting its intracellular signal transduction can reduce cancer cells viability and inhibit their growth. The targets and drugs identified show promising potential to serve as novel RCC therapeutics and prognostic markers. This review aims to summarize the current status quo regarding recent research on RCC focusing on the involvement of the Wnt/β-catenin pathway and how its understanding could facilitate the identification of potential therapeutic targets, new drugs and diagnostic biomarkers." @default.
- W2440181709 created "2016-06-24" @default.
- W2440181709 creator A5001637950 @default.
- W2440181709 creator A5031230636 @default.
- W2440181709 creator A5044475923 @default.
- W2440181709 creator A5054582820 @default.
- W2440181709 date "2016-06-17" @default.
- W2440181709 modified "2023-10-14" @default.
- W2440181709 title "Wnt Signaling in Renal Cell Carcinoma" @default.
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