FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2440183676> ?p ?o ?g. }

• W2440183676 endingPage "199" @default.
• W2440183676 startingPage "190" @default.
• W2440183676 abstract "The objective of the study was to develop solid self micro emulsifying drug delivery system (SSMED) for enhancement of oral bioavailability of losartan (LOS). Solubility of LOS in various vehicles was determined. Micro emulsion region was identified by constructing phase diagram containing surfactant: co-surfactant mixture (1:1 and 2:1), oil and water. Formulations were initially checked for droplet size upon addition to water. The formulations, which resulted in <200 nm size were further evaluated for self micro emulsification time, phase separation, effect of dilution and pH on droplet size, freeze-thaw stability. The optimized formulation (SMEDDS-C2) was positively charged and contained Capmul MCM 24%; Cremophor EL 37.5%; Transcutol P 37.5% and 1% stearyl amine and had an average particle size 142.51 ± 3.46 nm, zeta potential of +16.66 ± 0.46 mV. The SSMEDs were prepared by adsorption on 4 different carriers. Based on micromeritics, SSMED containing neusilin US2 (SSMED-N) was selected, characterized by DSC, XRD, SEM studies and in vitro dissolution. The in vitro release from liquid SMEDDS and SSMED-N was found to be significantly higher than LOS. The relative bioavailability of cationic SSMED-N in wistar rats was 2.82 times more than a drug suspension and stable for 3 months at room temperature (RT)." @default.
• W2440183676 created "2016-06-24" @default.
• W2440183676 creator A5008499029 @default.
• W2440183676 creator A5078794365 @default.
• W2440183676 date "2016-10-01" @default.
• W2440183676 modified "2023-10-14" @default.
• W2440183676 title "Cationic solid self micro emulsifying drug delivery system (SSMED) of losartan: Formulation development, characterization and in vivo evaluation" @default.
• W2440183676 cites W1965565422 @default.
• W2440183676 cites W1966990424 @default.
• W2440183676 cites W1967303320 @default.
• W2440183676 cites W1967773336 @default.
• W2440183676 cites W1967935934 @default.
• W2440183676 cites W1981468523 @default.
• W2440183676 cites W1982614387 @default.
• W2440183676 cites W1987913373 @default.
• W2440183676 cites W1994183479 @default.
• W2440183676 cites W1999026740 @default.
• W2440183676 cites W2014688741 @default.
• W2440183676 cites W2022870730 @default.
• W2440183676 cites W2023389877 @default.
• W2440183676 cites W2023537271 @default.
• W2440183676 cites W2036270563 @default.
• W2440183676 cites W2039739006 @default.
• W2440183676 cites W2039959526 @default.
• W2440183676 cites W2040309665 @default.
• W2440183676 cites W2043303830 @default.
• W2440183676 cites W2044872933 @default.
• W2440183676 cites W2048385095 @default.
• W2440183676 cites W2048760599 @default.
• W2440183676 cites W2059144066 @default.
• W2440183676 cites W2059225643 @default.
• W2440183676 cites W2064910281 @default.
• W2440183676 cites W2068886062 @default.
• W2440183676 cites W2074207007 @default.
• W2440183676 cites W2076863626 @default.
• W2440183676 cites W2082209609 @default.
• W2440183676 cites W2098455111 @default.
• W2440183676 cites W2107228338 @default.
• W2440183676 cites W2111000375 @default.
• W2440183676 cites W2138430919 @default.
• W2440183676 cites W2167207135 @default.
• W2440183676 cites W3080946385 @default.
• W2440183676 doi "https://doi.org/10.1016/j.jddst.2016.04.011" @default.
• W2440183676 hasPublicationYear "2016" @default.
• W2440183676 type Work @default.
• W2440183676 sameAs 2440183676 @default.
• W2440183676 citedByCount "12" @default.
• W2440183676 countsByYear W24401836762018 @default.
• W2440183676 countsByYear W24401836762019 @default.
• W2440183676 countsByYear W24401836762020 @default.
• W2440183676 countsByYear W24401836762021 @default.
• W2440183676 countsByYear W24401836762022 @default.
• W2440183676 countsByYear W24401836762023 @default.
• W2440183676 crossrefType "journal-article" @default.
• W2440183676 hasAuthorship W2440183676A5008499029 @default.
• W2440183676 hasAuthorship W2440183676A5078794365 @default.
• W2440183676 hasConcept C147789679 @default.
• W2440183676 hasConcept C155574463 @default.
• W2440183676 hasConcept C155672457 @default.
• W2440183676 hasConcept C171250308 @default.
• W2440183676 hasConcept C178790620 @default.
• W2440183676 hasConcept C181389837 @default.
• W2440183676 hasConcept C185592680 @default.
• W2440183676 hasConcept C187530423 @default.
• W2440183676 hasConcept C192562407 @default.
• W2440183676 hasConcept C2778123984 @default.
• W2440183676 hasConcept C2779820397 @default.
• W2440183676 hasConcept C43617362 @default.
• W2440183676 hasConcept C55493867 @default.
• W2440183676 hasConcept C58226133 @default.
• W2440183676 hasConcept C71924100 @default.
• W2440183676 hasConcept C86181022 @default.
• W2440183676 hasConcept C88380143 @default.
• W2440183676 hasConcept C98274493 @default.
• W2440183676 hasConceptScore W2440183676C147789679 @default.
• W2440183676 hasConceptScore W2440183676C155574463 @default.
• W2440183676 hasConceptScore W2440183676C155672457 @default.
• W2440183676 hasConceptScore W2440183676C171250308 @default.
• W2440183676 hasConceptScore W2440183676C178790620 @default.
• W2440183676 hasConceptScore W2440183676C181389837 @default.
• W2440183676 hasConceptScore W2440183676C185592680 @default.
• W2440183676 hasConceptScore W2440183676C187530423 @default.
• W2440183676 hasConceptScore W2440183676C192562407 @default.
• W2440183676 hasConceptScore W2440183676C2778123984 @default.
• W2440183676 hasConceptScore W2440183676C2779820397 @default.
• W2440183676 hasConceptScore W2440183676C43617362 @default.
• W2440183676 hasConceptScore W2440183676C55493867 @default.
• W2440183676 hasConceptScore W2440183676C58226133 @default.
• W2440183676 hasConceptScore W2440183676C71924100 @default.
• W2440183676 hasConceptScore W2440183676C86181022 @default.
• W2440183676 hasConceptScore W2440183676C88380143 @default.
• W2440183676 hasConceptScore W2440183676C98274493 @default.
• W2440183676 hasFunder F4320320736 @default.
• W2440183676 hasLocation W24401836761 @default.
• W2440183676 hasOpenAccess W2440183676 @default.
• W2440183676 hasPrimaryLocation W24401836761 @default.
• W2440183676 hasRelatedWork W1895149194 @default.
• W2440183676 hasRelatedWork W2045015004 @default.

• next