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- W244027218 abstract "Objective To study the dynamic ultrastructural changes of bladder tumors in phospholipase Ce+/(+PLCe+/+)or PLCe knock out(PLCe-/-)mouse and discuss the role of PLCe in bladder carcinogenesis.Methods Seventy two PLCe+/+ or PLCe-/-mouse were randomly divided into two groups respectively.The mice in two groups were watered with 0.05% BBN in tap water and bred for 18 weeks.The model mice were sacrificed in different periods and subcellular alteration of bladder tumors were examined under electron microscopy.Results The bladder cancinogenesis underwent has three successive stages in PLCe+/+ and PLCe-/-mice,including epithelial hyperplasia,papilloma and cancer.The changes of superficial transitional cells were significant.The main morphological changes of the cells were transformation of asymmetric unit membrane,appearance of irregular microvilli,loss of shuttle-like vesicles,decrease of microfilaments and junctional complexes,increase of intracytoplasmic lysosome and occurrence of signetring cells,absence of nuclear fibrous lamina.We considered that these were pathognomonic morphologic features of early cancerous changes.Conclusion PLCe-/-mice showed significant delay upon tumor onset compared with PLCe+/+ mice.The frequency of tumorigenesis in PLCe-/-mice was lower than that in PLCe+/+ mice.These results indicated that PLCe deficiency could inhibit the formation of bladder tumor." @default.
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- W244027218 date "2009-01-01" @default.
- W244027218 modified "2023-09-26" @default.
- W244027218 title "The ultrastructural alteration of lesion cells during BBN-induced bladder carcinogenesis in PLCε knock-out mouse." @default.
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