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- W2440373478 abstract "25 elderly hypertensive patients (mean age 66.5 +/- 5.0 years) were given enalapril (E) 20-40 mg daily, or calcium channel blockers (CCB): either slow-release nifedipine (40 mg) or long-acting verapamil (120-360 mg) daily, 6 weeks each, in a single-blind crossover study. At the end of each treatment period cerebral blood flow (CBF) was assessed by single proton emission, computed tomography, using 99m-Tc-exametazime. In the 20 patients who completed the study, supine BP was lowered from 194/106 to 167/90 mmHg (p less than 0.001/0.001) by E and from 185/104 to 172/91 (p less than 0.01/0.001) by CCB. Standing BP was lowered from 184/106 to 160/93 (p less than 0.001/0.001) by E and from 175/102 to 162/93 (p less than 0.01/0.01) by CCB. Although there were great interpatient differences in CBF, the individual pattern remained unaltered by either E or CCB and mean quantitative changes were not significant. We conclude that in elderly hypertensives both E and CCB effectively lower BP, while cerebral perfusion is not adversely affected by either." @default.
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- W2440373478 date "1992-03-15" @default.
- W2440373478 modified "2023-09-23" @default.
- W2440373478 title "[Cerebral blood flow in elderly hypertensives after enalapril of calcium channel blockers]." @default.
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